# GeDiPNet Cluster 425 -- Enriched Pathways -- generated 2026-10-08 09:44:52
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)	Reactome	1	SLC29A3	1	9	1334.44	7.494e-4	1.115e-2
Rho GTPase cycle	Reactome	2	ARHGAP24, OBSCN	138	9	19.34	4.476e-3	4.138e-2
Bicarbonate transporters	Reactome	1	SLC4A10	10	9	133.44	7.471e-3	5.806e-2
Synthesis of PE	Reactome	1	LPIN1	12	9	111.20	8.960e-3	6.534e-2
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	Reactome	1	SLC29A3	12	9	111.20	8.960e-3	6.534e-2
Triglyceride biosynthesis	Reactome	1	LPIN1	13	9	102.65	9.703e-3	6.873e-2
Depolymerisation of the Nuclear Lamina	Reactome	1	LPIN1	15	9	88.96	1.119e-2	7.510e-2
G1/S-Specific Transcription	Reactome	1	TYMS	24	9	55.60	1.785e-2	9.951e-2
Miscellaneous transport and binding events	Reactome	1	LRRC8B	25	9	53.38	1.859e-2	1.017e-1
Synthesis of PC	Reactome	1	LPIN1	28	9	47.66	2.079e-2	1.083e-1
Interconversion of nucleotide di- and triphosphates	Reactome	1	TYMS	29	9	46.02	2.153e-2	1.106e-1
Antifolate resistance	KEGG	1	TYMS	30	9	44.48	2.227e-2	1.126e-1
Folate transport and metabolism	KEGG	1	TYMS	31	9	43.05	2.300e-2	1.149e-1
Smooth Muscle Contraction	Reactome	1	DYSF	34	9	39.25	2.520e-2	1.209e-1
One carbon pool by folate	KEGG	1	TYMS	38	9	35.12	2.813e-2	1.280e-1