# GeDiPNet Cluster 422 -- Enriched Pathways -- generated 2026-10-08 04:12:41
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Metabolism of folate and pterines	Reactome	2	SLC46A1, DHFR	17	15	94.20	1.959e-4	3.885e-3
Vitamin digestion and absorption	KEGG	2	SLC46A1, TCN2	26	15	61.59	4.651e-4	7.703e-3
Folate biosynthesis	KEGG	2	DHFR, MOCOS	28	15	57.19	5.401e-4	8.627e-3
Antifolate resistance	KEGG	2	SLC46A1, DHFR	30	15	53.38	6.207e-4	9.633e-3
Folate transport and metabolism	KEGG	2	SLC46A1, DHFR	31	15	51.66	6.630e-4	1.014e-2
Defective TCN2 causes hereditary megaloblastic anemia	Reactome	1	TCN2	1	15	800.67	1.249e-3	1.645e-2
Defective CD320 causes methylmalonic aciduria	Reactome	1	TCN2	2	15	400.33	2.496e-3	2.744e-2
Coronavirus disease - COVID-19	KEGG	3	CSF3, RPL17, RPL27A	238	15	10.09	2.931e-3	3.076e-2
Toll Like Receptor 3 (TLR3) Cascade	Reactome	1	SARM1	3	15	266.89	3.743e-3	3.650e-2
Chronic myeloid leukemia	KEGG	2	MECOM, RUNX1	77	15	20.80	4.036e-3	3.852e-2
RUNX2 regulates genes involved in differentiation of myeloid cells	Reactome	1	RUNX1	4	15	200.17	4.987e-3	4.437e-2
Viral mRNA Translation	Reactome	2	RPL17, RPL27A	89	15	17.99	5.355e-3	4.672e-2
SRP-dependent cotranslational protein targeting to membrane	Reactome	2	RPL17, RPL27A	93	15	17.22	5.833e-3	4.953e-2
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Reactome	2	RPL17, RPL27A	95	15	16.86	6.080e-3	5.091e-2
RUNX1 regulates expression of components of tight junctions	Reactome	1	RUNX1	5	15	160.13	6.230e-3	5.168e-2