# GeDiPNet Cluster 418 -- Enriched Pathways -- generated 2026-10-08 05:01:12
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Prostate cancer	KEGG	4	PDGFB, KLK3, SRD5A2, PDGFD	98	21	23.34	2.243e-5	6.706e-4
MAPK signaling pathway	KEGG	5	CACNA2D2, FGF7, PDGFB, PDGFD, CACNA1B	299	21	9.56	1.356e-4	2.900e-3
Androgen biosynthesis	Reactome	2	SRD5A2, SRD5A1	11	21	103.98	1.586e-4	3.281e-3
Presynaptic depolarization and calcium channel opening	Reactome	2	CACNA2D2, CACNA1B	12	21	95.32	1.902e-4	3.806e-3
Melanoma	KEGG	3	FGF7, PDGFB, PDGFD	73	21	23.50	2.649e-4	4.923e-3
Rap1 signaling pathway	KEGG	4	FPR1, FGF7, PDGFB, PDGFD	211	21	10.84	4.382e-4	7.351e-3
Calcium signaling pathway	KEGG	4	FGF7, PDGFB, PDGFD, CACNA1B	254	21	9.01	8.806e-4	1.261e-2
Signaling by PDGF	Reactome	2	PDGFB, PDGFD	33	21	34.66	1.488e-3	1.886e-2
PI3K-Akt signaling pathway	KEGG	4	FGF7, PDGFB, PRL, PDGFD	361	21	6.34	3.203e-3	3.266e-2
Steroid hormone biosynthesis	KEGG	2	SRD5A2, SRD5A1	63	21	18.16	5.333e-3	4.657e-2
Regulation of actin cytoskeleton	KEGG	3	FGF7, PDGFB, PDGFD	232	21	7.40	7.318e-3	5.742e-2
Constitutive Signaling by Aberrant PI3K in Cancer	Reactome	2	FGF7, PDGFB	75	21	15.25	7.483e-3	5.808e-2
Ras signaling pathway	KEGG	3	FGF7, PDGFB, PDGFD	237	21	7.24	7.760e-3	5.967e-2
EGFR tyrosine kinase inhibitor resistance	KEGG	2	PDGFB, PDGFD	80	21	14.30	8.477e-3	6.315e-2
Gap junction	KEGG	2	PDGFB, PDGFD	89	21	12.85	1.041e-2	7.192e-2