# GeDiPNet Cluster 414 -- Enriched Pathways -- generated 2026-10-07 13:59:34
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Platelet activation	KEGG	7	GP6, ITGB3, GP1BA, P2RY12, VWF, ITGA2, ITGA2B	126	19	35.12	5.368e-10	6.473e-8
ECM-receptor interaction	KEGG	6	GP6, ITGB3, GP1BA, VWF, ITGA2, ITGA2B	89	19	42.61	3.506e-9	3.439e-7
Platelet Adhesion to exposed collagen	Reactome	3	GP6, GP1BA, VWF	11	19	172.39	5.495e-7	2.912e-5
p130Cas linkage to MAPK signaling for integrins	Reactome	3	ITGB3, VWF, ITGA2B	15	19	126.42	1.509e-6	6.951e-5
GRB2:SOS provides linkage to MAPK signaling for Integrins 	Reactome	3	ITGB3, VWF, ITGA2B	15	19	126.42	1.509e-6	6.951e-5
Integrin signaling	Reactome	3	ITGB3, VWF, ITGA2B	23	19	82.45	5.828e-6	2.147e-4
Integrin cell surface interactions	Reactome	4	ITGB3, VWF, ITGA2, ITGA2B	81	19	31.22	6.890e-6	2.456e-4
Hematopoietic cell lineage	KEGG	4	ITGB3, GP1BA, ITGA2, ITGA2B	100	19	25.28	1.593e-5	4.954e-4
Signaling by high-kinase activity BRAF mutants	Reactome	3	ITGB3, VWF, ITGA2B	36	19	52.68	2.319e-5	6.740e-4
MAP2K and MAPK activation	Reactome	3	ITGB3, VWF, ITGA2B	40	19	47.41	3.196e-5	8.808e-4
Signaling by moderate kinase activity BRAF mutants	Reactome	3	ITGB3, VWF, ITGA2B	47	19	40.35	5.209e-5	1.323e-3
Paradoxical activation of RAF signaling by kinase inactive BRAF	Reactome	3	ITGB3, VWF, ITGA2B	47	19	40.35	5.209e-5	1.323e-3
Signaling downstream of RAS mutants	Reactome	3	ITGB3, VWF, ITGA2B	47	19	40.35	5.209e-5	1.323e-3
Platelet Aggregation (Plug Formation)	Reactome	2	GP1BA, VWF	8	19	158.03	6.602e-5	1.598e-3
ECM proteoglycans	Reactome	3	ITGB3, ITGA2, ITGA2B	51	19	37.18	6.663e-5	1.612e-3