# GeDiPNet Cluster 410 -- Enriched Pathways -- generated 2026-10-07 21:16:25
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Cation-coupled Chloride cotransporters	Reactome	2	SLC12A1, SLC12A3	7	11	311.95	1.598e-5	4.959e-4
Stimuli-sensing channels	Reactome	3	BSND, CLCNKB, CLCNKA	79	11	41.46	4.352e-5	1.141e-3
Defective SLC17A5 causes Salla disease (SD) and ISSD	Reactome	1	SLC17A5	1	11	1091.82	9.159e-4	1.268e-2
MPS I - Hurler syndrome	Reactome	1	IDUA	1	11	1091.82	9.159e-4	1.268e-2
Defective SLC12A1 causes Bartter syndrome 1 (BS1)	Reactome	1	SLC12A1	1	11	1091.82	9.159e-4	1.268e-2
Defective SLC12A3 causes Gitelman syndrome (GS)	Reactome	1	SLC12A3	1	11	1091.82	9.159e-4	1.268e-2
Potassium transport channels	Reactome	1	KCNJ1	3	11	363.94	2.745e-3	2.889e-2
Parathyroid hormone synthesis, secretion and action	KEGG	2	CASR, SLC12A3	115	11	18.99	4.725e-3	4.222e-2
Lysosome	KEGG	2	IDUA, SLC17A5	133	11	16.42	6.271e-3	5.082e-2
Organic anion transporters	Reactome	1	SLC17A5	10	11	109.18	9.125e-3	6.495e-2
CS/DS degradation	Reactome	1	IDUA	14	11	77.99	1.275e-2	7.893e-2
Metabolism of Angiotensinogen to Angiotensins	Reactome	1	REN	17	11	64.22	1.547e-2	8.860e-2
Glycosaminoglycan degradation	KEGG	1	IDUA	19	11	57.46	1.727e-2	9.499e-2
HS-GAG degradation	Reactome	1	IDUA	22	11	49.63	1.997e-2	1.027e-1
Renin-angiotensin system	KEGG	1	REN	23	11	47.47	2.087e-2	1.053e-1