# GeDiPNet Cluster 41 -- Top Shared Genes -- generated 2026-10-07 15:55:30
# Curated genes (disease_gdp) linked to 2 or more of this cluster's member diseases, most widely shared first. Data as of: 2026-10-07 03:15:01.
Gene	Member Diseases Linked	Cluster Size	Linked Diseases
NKX2-5	7	16	Atrial septal defect; Congenital heart disease; Congenital heart septal defect; Conotruncal cardiac defect; Hypoplastic left heart syndrome; Tetralogy of fallot; Ventricular septal defect
TBX1	7	16	Congenital heart defects; Congenital heart disease; Conotruncal cardiac defect; Craniofacial abnormalities; Hypoplastic left heart syndrome; Tetralogy of fallot; Ventricular septal defect
GATA4	6	16	Atrial septal defect; Congenital heart defects; Congenital heart disease; Congenital heart septal defect; Tetralogy of fallot; Ventricular septal defect
TBX20	6	16	Atrial septal defect; Congenital heart disease; Hypoplastic left heart syndrome; Right hypoplastic heart syndrome; Tetralogy of fallot; Ventricular septal defect
AHR	5	16	Congenital heart defects; Congenital heart disease; Conotruncal cardiac defect; Craniofacial abnormalities; Growth disorder
CITED2	5	16	Atrial septal defect; Congenital heart disease; Congenital heart septal defect; Tetralogy of fallot; Ventricular septal defect
GATA6	5	16	Atrial septal defect; Congenital heart defects; Conotruncal cardiac defect; Tetralogy of fallot; Ventricular septal defect
MYH6	5	16	Atrial septal defect; Congenital heart defects; Congenital heart septal defect; Hypoplastic left heart syndrome; Tetralogy of fallot
FOXP1	4	16	Atrial septal defect; Congenital heart defects; Congenital heart disease; Hypoplastic left heart syndrome
GDF1	4	16	Congenital heart defects; Congenital heart disease; Conotruncal cardiac defect; Tetralogy of fallot
ISL1	4	16	Atrial septal defect; Congenital heart defects; Congenital heart disease; Ventricular septal defect
MYH7	4	16	Congenital heart defects; Congenital heart disease; Hypoplastic left heart syndrome; Tetralogy of fallot
NIPBL	4	16	Congenital heart defects; Congenital heart disease; Craniofacial abnormalities; Tetralogy of fallot
NKX2-6	4	16	Congenital heart disease; Conotruncal cardiac defect; Tetralogy of fallot; Ventricular septal defect
NOTCH1	4	16	Congenital heart disease; Craniofacial abnormalities; Hypoplastic left heart syndrome; Tetralogy of fallot
PQBP1	4	16	Atrial septal defect; Congenital heart septal defect; Growth disorder; renpenning syndrome
ROBO1	4	16	Atrial septal defect; Congenital heart disease; Congenital heart septal defect; Tetralogy of fallot
TBX5	4	16	Atrial septal defect; Congenital heart disease; Tetralogy of fallot; Ventricular septal defect
TGFB2	4	16	Atrial septal defect; Congenital heart defects; Congenital heart disease; Craniofacial abnormalities
ABL1	3	16	Congenital heart defects; Congenital heart disease; Tetralogy of fallot
CERS1	3	16	Congenital heart defects; Congenital heart disease; Tetralogy of fallot
CRELD1	3	16	Congenital heart disease; Tetralogy of fallot; Ventricular septal defect
CRIPTO	3	16	Congenital heart defects; Congenital heart disease; Tetralogy of fallot
FLNA	3	16	Congenital heart defects; Tetralogy of fallot; Ventricular septal defect
FOXH1	3	16	congenital heart disease; Conotruncal cardiac defect; Tetralogy of fallot
FOXP2	3	16	Congenital heart disease; Conotruncal cardiac defect; Craniofacial abnormalities
GATA5	3	16	Congenital heart disease; Tetralogy of fallot; Ventricular septal defect
HAND1	3	16	Congenital heart disease; Hypoplastic left heart syndrome; Tetralogy of fallot
HAND2	3	16	Congenital heart defects; Congenital heart disease; Tetralogy of fallot
IRX4	3	16	Congenital heart disease; Tetralogy of fallot; Ventricular septal defect
LEFTY2	3	16	Congenital heart defects; Congenital heart disease; Tetralogy of fallot
MCTP2	3	16	Chromosome 15q deletion syndrome; Congenital heart disease; Tetralogy of fallot
NFATC1	3	16	Congenital heart defects; Congenital heart disease; Ventricular septal defect
PITX2	3	16	Congenital heart defects; Congenital heart disease; Craniofacial abnormalities
RBFOX2	3	16	Congenital heart disease; Hypoplastic left heart syndrome; Tetralogy of fallot
RCAN1	3	16	Congenital heart defects; Congenital heart disease; Craniofacial abnormalities
SALL4	3	16	Congenital heart septal defect; Craniofacial abnormalities; Ventricular septal defect
SMARCA4	3	16	Atrial septal defect; Tetralogy of fallot; Ventricular septal defect
STRA6	3	16	Congenital heart defects; Congenital heart disease; Craniofacial abnormalities
TLL1	3	16	Atrial septal defect; Congenital heart disease; Tetralogy of fallot
UFD1	3	16	Congenital heart defects; Congenital heart disease; Craniofacial abnormalities
ZIC3	3	16	Congenital heart disease; Craniofacial abnormalities; Tetralogy of fallot
ACTC1	2	16	Atrial septal defect; Tetralogy of fallot
ADAM29	2	16	Congenital heart disease; Conotruncal cardiac defect
ADAMTS19	2	16	Congenital heart defects; Congenital heart disease
AFF4	2	16	Congenital heart defects; Growth disorder
ANKRD1	2	16	Congenital heart disease; Tetralogy of fallot
ANKRD11	2	16	Congenital heart disease; Tetralogy of fallot
ATRX	2	16	Craniofacial abnormalities; Growth disorder
BMP2	2	16	Atrial septal defect; Ventricular septal defect
BMP7	2	16	Congenital heart disease; Ventricular septal defect
BMPR1A	2	16	Congenital heart disease; Craniofacial abnormalities
BRAF	2	16	Tetralogy of fallot; Ventricular septal defect
CARTPT	2	16	Congenital heart disease; Conotruncal cardiac defect
CDH13	2	16	Congenital heart disease; Conotruncal cardiac defect
CDK13	2	16	Congenital heart defects; Congenital heart disease
CFAP53	2	16	Hypoplastic left heart syndrome; Tetralogy of fallot
CHD7	2	16	Atrial septal defect; Tetralogy of fallot
CNTN4	2	16	Craniofacial abnormalities; Growth disorder
COL11A2	2	16	Congenital heart defects; Craniofacial abnormalities
COL1A2	2	16	Congenital heart disease; Ventricular septal defect
COL2A1	2	16	Congenital heart defects; Craniofacial abnormalities
CTSG	2	16	Congenital heart disease; Conotruncal cardiac defect
CUL9	2	16	Atrial septal defect; Ventricular septal defect
DCHS1	2	16	Congenital heart disease; Tetralogy of fallot
DDB1	2	16	Congenital heart defects; White-kernohan syndrome
DNMT3A	2	16	Craniofacial abnormalities; Growth disorder
ECE1	2	16	Congenital heart defects; Craniofacial abnormalities
EDN1	2	16	Congenital heart defects; Craniofacial abnormalities
EDNRA	2	16	Congenital heart defects; Craniofacial abnormalities
EPO	2	16	Congenital heart septal defect; Ventricular septal defect
ERCC6	2	16	Craniofacial abnormalities; Growth disorder
ETV2	2	16	Congenital heart defects; Hypoplastic left heart syndrome
EYA1	2	16	Congenital heart defects; Craniofacial abnormalities
FBN2	2	16	Tetralogy of fallot; Ventricular septal defect
FGD1	2	16	Craniofacial abnormalities; Growth disorder
FGF8	2	16	Congenital heart disease; Craniofacial abnormalities
FLT4	2	16	Congenital heart disease; Tetralogy of fallot
FOLR1	2	16	Congenital heart defects; Craniofacial abnormalities
FOXC2	2	16	Craniofacial abnormalities; Tetralogy of fallot
FOXL1	2	16	Congenital heart disease; Tetralogy of fallot
GJA1	2	16	Congenital heart disease; Hypoplastic left heart syndrome
GJA5	2	16	Congenital heart disease; Tetralogy of fallot
GNAQ	2	16	Congenital heart defects; Craniofacial abnormalities
GP1BB	2	16	Congenital heart defects; Craniofacial abnormalities
H4C3	2	16	Craniofacial abnormalities; Growth disorder
HEY2	2	16	Congenital heart disease; Tetralogy of fallot
HOXA1	2	16	Congenital heart defects; Craniofacial abnormalities
HOXA3	2	16	Congenital heart defects; Craniofacial abnormalities
HSPBAP1	2	16	Atrial septal defect; Congenital heart septal defect
HUWE1	2	16	Atrial septal defect; Ventricular septal defect
IDH2	2	16	Craniofacial abnormalities; Growth disorder
IQCJ	2	16	Congenital heart disease; Conotruncal cardiac defect
IQCJ-SCHIP1	2	16	Congenital heart disease; Conotruncal cardiac defect
IRX5	2	16	Congenital heart defects; Craniofacial abnormalities
JAG1	2	16	Congenital heart defects; Tetralogy of fallot
KCNN2	2	16	Congenital heart disease; Congenital heart septal defect
KDM5A	2	16	Congenital heart disease; El-hayek-chahrour neurodevelopmental syndrome
LPAR1	2	16	Craniofacial abnormalities; Growth disorder
LRP2	2	16	Congenital heart disease; Craniofacial abnormalities
LTBP3	2	16	Craniofacial abnormalities; Growth disorder
MAP1B	2	16	Congenital heart disease; Conotruncal cardiac defect
MED13L	2	16	Congenital heart disease; Tetralogy of fallot
MTHFR	2	16	Congenital heart defects; Tetralogy of fallot
MYH11	2	16	Congenital heart disease; Tetralogy of fallot
MYRF	2	16	Congenital heart defects; Tetralogy of fallot
NONO	2	16	Congenital heart disease; Tetralogy of fallot
NPPB	2	16	Congenital heart defects; Congenital heart disease
NR2F2	2	16	Congenital heart disease; Tetralogy of fallot
NRP1	2	16	Congenital heart disease; Tetralogy of fallot
PARP14	2	16	Atrial septal defect; Congenital heart septal defect
PCSK5	2	16	Congenital heart septal defect; Ventricular septal defect
PDGFRA	2	16	Congenital heart disease; Craniofacial abnormalities
PLXND1	2	16	Congenital heart disease; Tetralogy of fallot
POU5F1	2	16	Congenital heart defects; Congenital heart disease
PRKD1	2	16	Congenital heart disease; Tetralogy of fallot
PTCH1	2	16	Congenital heart disease; Craniofacial abnormalities
RAB40AL	2	16	Craniofacial abnormalities; Growth disorder
RAI1	2	16	Craniofacial abnormalities; Growth disorder
SCHIP1	2	16	Congenital heart disease; Conotruncal cardiac defect
SETBP1	2	16	Atrial septal defect; Craniofacial abnormalities
SH3PXD2B	2	16	Craniofacial abnormalities; Growth disorder
SLC29A3	2	16	Congenital heart defects; Congenital heart disease
SMAD2	2	16	Congenital heart disease; Craniofacial abnormalities
SMAD6	2	16	Congenital heart disease; Tetralogy of fallot
SOS1	2	16	Atrial septal defect; Tetralogy of fallot
SOX7	2	16	Congenital heart disease; Tetralogy of fallot
SRF	2	16	Congenital heart disease; Tetralogy of fallot
TAB2	2	16	Congenital heart disease; Tetralogy of fallot
TAF1	2	16	Congenital heart disease; Tetralogy of fallot
TBX15	2	16	Craniofacial abnormalities; Growth disorder
TCF21	2	16	Congenital heart disease; Ventricular septal defect
TFAP2B	2	16	Craniofacial abnormalities; Tetralogy of fallot
TMEM260	2	16	Tetralogy of fallot; Truncus arteriosus
TPM1	2	16	Atrial septal defect; Tetralogy of fallot
VEGFA	2	16	Congenital heart defects; Congenital heart disease
YES1	2	16	Congenital heart septal defect; Ventricular septal defect
YTHDC2	2	16	Congenital heart disease; Congenital heart septal defect
ZEB2	2	16	Congenital heart defects; Congenital heart disease
ZFPM2	2	16	Conotruncal cardiac defect; Tetralogy of fallot