# GeDiPNet Cluster 41 -- Enriched Pathways -- generated 2026-10-09 16:24:49
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Energy dependent regulation of mTOR by LKB1-AMPK	Reactome	4	TSC2, MTOR, RHEB, TSC1	29	23	72.02	2.352e-7	1.324e-5
Macroautophagy	Reactome	4	TSC2, MTOR, RHEB, TSC1	68	23	30.72	7.674e-6	2.603e-4
Inhibition of TSC complex formation by PKB	Reactome	2	TSC2, TSC1	3	23	348.12	1.051e-5	3.385e-4
TP53 Regulates Metabolic Genes	Reactome	4	TSC2, MTOR, RHEB, TSC1	86	23	24.29	1.956e-5	5.730e-4
Herpes simplex virus 1 infection	KEGG	5	TSC2, MTOR, RHEB, TSC1, IFNG	182	23	14.35	2.039e-5	5.932e-4
Longevity regulating pathway	KEGG	4	TSC2, MTOR, RHEB, TSC1	90	23	23.21	2.342e-5	6.668e-4
Choline metabolism in cancer	KEGG	4	TSC2, MTOR, RHEB, TSC1	99	23	21.10	3.411e-5	9.087e-4
HIF-1 signaling pathway	KEGG	4	MTOR, NOS3, VHL, IFNG	110	23	18.99	5.158e-5	1.272e-3
AMPK signaling pathway	KEGG	4	TSC2, MTOR, RHEB, TSC1	122	23	17.12	7.729e-5	1.765e-3
Insulin signaling pathway	KEGG	4	TSC2, MTOR, RHEB, TSC1	138	23	15.14	1.247e-4	2.601e-3
Displacement of DNA glycosylase by APEX1	Reactome	2	MUTYH, NTHL1	9	23	116.04	1.253e-4	2.611e-3
Amino acids regulate mTORC1	Reactome	3	SZT2, MTOR, RHEB	55	23	28.48	1.508e-4	3.037e-3
Phospholipase D signaling pathway	KEGG	4	TSC2, MTOR, RHEB, TSC1	149	23	14.02	1.677e-4	3.316e-3
Cellular senescence	KEGG	4	TSC2, MTOR, RHEB, TSC1	157	23	13.30	2.050e-4	3.877e-3
mTOR signaling pathway	KEGG	4	TSC2, MTOR, RHEB, TSC1	158	23	13.22	2.101e-4	3.945e-3