# GeDiPNet Cluster 407 -- Enriched Pathways -- generated 2026-10-07 18:51:19
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	Reactome	2	CYP2C8, CYP2J2	8	12	250.21	2.554e-5	7.280e-4
Lipid and atherosclerosis	KEGG	4	NLRP3, CYP2C8, CYP2J2, HSPA8	216	12	18.53	4.498e-5	1.172e-3
Xenobiotics	Reactome	2	CYP2C8, CYP2J2	24	12	83.40	2.495e-4	4.643e-3
Vascular smooth muscle contraction	KEGG	3	MYH9, AGT, NPPA	134	12	22.41	2.776e-4	5.051e-3
Linoleic acid metabolism	KEGG	2	CYP2C8, CYP2J2	30	12	66.72	3.920e-4	6.610e-3
Pathogenic Escherichia coli infection	KEGG	3	NLRP3, MYH9, MYO6	200	12	15.01	8.958e-4	1.249e-2
Arachidonic acid metabolism	KEGG	2	CYP2C8, CYP2J2	63	12	31.77	1.728e-3	2.050e-2
Renin secretion	KEGG	2	AGT, NPPA	69	12	29.01	2.069e-3	2.340e-2
Aldosterone synthesis and secretion	KEGG	2	AGT, NPPA	98	12	20.43	4.124e-3	3.856e-2
Serotonergic synapse	KEGG	2	CYP2C8, CYP2J2	115	12	17.41	5.634e-3	4.741e-2
Biosynthesis of maresin-like SPMs	Reactome	1	CYP2C8	6	12	166.81	5.981e-3	4.925e-2
Clathrin-mediated endocytosis	Reactome	2	BIN1, HSPA8	130	12	15.40	7.148e-3	5.543e-2
CD163 mediating an anti-inflammatory response	Reactome	1	MYH9	9	12	111.20	8.960e-3	6.417e-2
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	Reactome	1	CYP2C8	9	12	111.20	8.960e-3	6.417e-2
CYP2E1 reactions	Reactome	1	CYP2C8	11	12	90.98	1.094e-2	7.246e-2