# GeDiPNet Cluster 4 -- Enriched Pathways -- generated 2026-10-09 00:09:11
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Pathways in cancer	KEGG	98	TP53, APC, CDKN2A, CTNNB1, KRAS, PTEN, JAK1, BAK1, CEBPA, FLT3, IL7, NFKB1	533	494	4.47	3.591e-38	1.811e-34
Prostate cancer	KEGG	36	TP53, CTNNB1, KRAS, PTEN, ERG, NFKB1, CCND1, PDGFRA, RB1, AKT1, BRAF, ERBB2	98	494	8.93	2.811e-25	4.394e-22
EGFR tyrosine kinase inhibitor resistance	KEGG	33	KRAS, PTEN, JAK1, PDGFRA, JAK2, STAT3, AKT1, BRAF, ERBB2, MET, MTOR, FGFR3	80	494	10.03	3.450e-25	5.318e-22
Transcriptional misregulation in cancer	KEGG	47	TP53, BAK1, CEBPA, CEBPE, CSF2, ERG, FLT3, NFKB1, ATM, PBX1, TCF3, ETV6	198	494	5.77	2.608e-23	3.146e-20
Central carbon metabolism in cancer	KEGG	27	TP53, KRAS, PTEN, FLT3, GLS, PDGFRA, AKT1, ERBB2, MET, MYC, MTOR, FGFR3	71	494	9.25	1.040e-19	7.305e-17
PI3K-Akt signaling pathway	KEGG	58	TP53, IFNB1, KRAS, PTEN, JAK1, FLT3, IL7, MYB, NFKB1, CCND1, PDGFRA, BRCA1	361	494	3.91	1.486e-19	1.025e-16
Human T-cell leukemia virus 1 infection	KEGG	45	TP53, CDKN2A, KRAS, PTEN, JAK1, CSF2, NFKB1, ATM, CCND1, TCF3, HLA-C, CHEK2	224	494	4.88	2.985e-19	1.949e-16
Endocrine resistance	KEGG	30	TP53, CDKN2A, KRAS, CCND1, RB1, AKT1, BRAF, ERBB2, MTOR, CDKN1A, ESR2, HRAS	99	494	7.37	1.651e-18	9.798e-16
Kaposi sarcoma-associated herpesvirus infection	KEGG	41	TP53, IFNB1, CTNNB1, KRAS, JAK1, BAK1, CSF2, NFKB1, CCND1, HLA-C, RB1, JAK2	196	494	5.09	2.663e-18	1.547e-15
Non-small cell lung cancer	KEGG	26	TP53, CDKN2A, KRAS, BAK1, CCND1, RB1, STAT3, AKT1, BRAF, ERBB2, MET, CDKN1A	73	494	8.66	3.459e-18	1.939e-15
Cellular senescence	KEGG	36	TP53, CDKN2A, KRAS, PTEN, NFKB1, TRAF3IP2, ATM, CCND1, HLA-C, CHEK2, RB1, AKT1	157	494	5.57	1.436e-17	7.311e-15
Bladder cancer	KEGG	20	TP53, CDKN2A, KRAS, CCND1, RB1, BRAF, ERBB2, MYC, CDKN1A, DAPK1, FGFR3, HRAS	41	494	11.86	1.590e-17	8.055e-15
Pancreatic cancer	KEGG	26	TP53, CDKN2A, KRAS, JAK1, BAK1, NFKB1, CCND1, RB1, BRCA2, STAT3, AKT1, BRAF	77	494	8.21	1.607e-17	8.067e-15
Chronic myeloid leukemia	KEGG	26	TP53, CDKN2A, KRAS, BAK1, NFKB1, CCND1, ABL1, BCR, RB1, AKT1, BRAF, MYC	77	494	8.21	1.607e-17	8.067e-15
Human cytomegalovirus infection	KEGG	43	TP53, IFNB1, CDKN2A, CTNNB1, KRAS, JAK1, BAK1, CCL2, NFKB1, CCND1, PDGFRA, HLA-C	226	494	4.63	1.644e-17	8.182e-15