# GeDiPNet Cluster 386 -- Enriched Pathways -- generated 2026-10-08 10:56:20
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Stabilization of p53	Reactome	2	TP53, MDM4	11	10	218.36	3.418e-5	9.459e-4
Regulation of TP53 Activity through Methylation	Reactome	2	TP53, MDM4	19	10	126.42	1.059e-4	2.376e-3
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	Reactome	2	NPM1, TP53	20	10	120.10	1.176e-4	2.581e-3
Interleukin-3, Interleukin-5 and GM-CSF signaling	Reactome	2	CSF2, STAT5B	23	10	104.43	1.564e-4	3.242e-3
Oncogene Induced Senescence	Reactome	2	TP53, MDM4	33	10	72.79	3.250e-4	5.798e-3
Regulation of TP53 Degradation	Reactome	2	TP53, MDM4	36	10	66.72	3.872e-4	6.661e-3
Human T-cell leukemia virus 1 infection	KEGG	3	CSF2, TP53, STAT5B	224	10	16.08	6.973e-4	1.055e-2
Defective GCK causes maturity-onset diabetes of the young 2 (MODY2)	Reactome	1	GCK	1	10	1201.00	8.326e-4	1.209e-2
Acute myeloid leukemia	KEGG	2	CSF2, STAT5B	68	10	35.32	1.380e-3	1.776e-2
Prolactin signaling pathway	KEGG	2	GCK, STAT5B	71	10	33.83	1.504e-3	1.894e-2
Central carbon metabolism in cancer	KEGG	2	GCK, TP53	71	10	33.83	1.504e-3	1.894e-2
Non-small cell lung cancer	KEGG	2	TP53, STAT5B	73	10	32.90	1.589e-3	1.972e-2
Regulation of TP53 Expression	Reactome	1	TP53	2	10	600.50	1.665e-3	2.040e-2
Signaling by Leptin	Reactome	1	STAT5B	2	10	600.50	1.665e-3	2.040e-2
p53 signaling pathway	KEGG	2	TP53, MDM4	75	10	32.03	1.676e-3	2.050e-2