# GeDiPNet Cluster 37 -- Enriched Pathways -- generated 2026-10-09 04:56:55
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Gamma-carboxylation of protein precursors	Reactome	2	GGCX, PROS1	9	63	42.36	9.521e-4	1.291e-2
Glutathione metabolism	KEGG	3	GCLC, NAT8, GSTT1	59	63	9.69	3.628e-3	3.506e-2
Signaling by FGFR2 amplification mutants	Reactome	1	FGFR2	1	63	190.63	5.246e-3	4.514e-2
Signaling by FGFR2 fusions	Reactome	1	FGFR2	1	63	190.63	5.246e-3	4.514e-2
PTEN Loss of Function in Cancer	Reactome	1	PTEN	1	63	190.63	5.246e-3	4.514e-2
Common Pathway of Fibrin Clot Formation	Reactome	2	F5, PROS1	22	63	17.33	5.847e-3	4.856e-2
Central carbon metabolism in cancer	KEGG	3	FGFR2, SIRT3, PTEN	71	63	8.05	6.101e-3	5.009e-2
EGFR tyrosine kinase inhibitor resistance	KEGG	3	FGFR2, JAK2, PTEN	80	63	7.15	8.483e-3	6.235e-2
Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)	Reactome	1	GCLC	2	63	95.32	1.046e-2	7.135e-2
Transport to the Golgi and subsequent modification	Reactome	1	LMAN1	2	63	95.32	1.046e-2	7.135e-2
Reversal of alkylation damage by DNA dioxygenases	Reactome	1	FTO	2	63	95.32	1.046e-2	7.135e-2
Assembly of Viral Components at the Budding Site	Reactome	1	CALR	2	63	95.32	1.046e-2	7.135e-2
Complement and coagulation cascades	KEGG	3	F5, PLAU, PROS1	88	63	6.50	1.100e-2	7.359e-2
Cargo concentration in the ER	Reactome	2	F5, LMAN1	33	63	11.55	1.288e-2	8.105e-2
Prostate cancer	KEGG	3	FGFR2, PTEN, PLAU	98	63	5.84	1.469e-2	8.760e-2