# GeDiPNet Cluster 365 -- Enriched Pathways -- generated 2026-10-10 14:21:27
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-10 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
beta-Alanine metabolism	KEGG	2	ALDH7A1, GAD1	31	10	77.48	2.865e-4	5.331e-3
GABA synthesis	Reactome	1	GAD1	2	10	600.50	1.665e-3	2.073e-2
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	Reactome	1	POMT1	3	10	400.33	2.496e-3	2.775e-2
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	Reactome	1	POMT1	3	10	400.33	2.496e-3	2.775e-2
Sodium-coupled sulphate, di- and tri-carboxylate transporters	Reactome	1	SLC13A5	5	10	240.20	4.157e-3	3.987e-2
Assembly and cell surface presentation of NMDA receptors	Reactome	1	GRIN2A	6	10	200.17	4.986e-3	4.510e-2
Choline catabolism	Reactome	1	ALDH7A1	6	10	200.17	4.986e-3	4.510e-2
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	Reactome	1	PNKP	7	10	171.57	5.815e-3	5.013e-2
O-linked glycosylation	Reactome	1	POMT1	10	10	120.10	8.298e-3	6.281e-2
Lysine catabolism	Reactome	1	ALDH7A1	12	10	100.08	9.951e-3	7.054e-2
GABA synthesis, release, reuptake and degradation	Reactome	1	GAD1	13	10	92.38	1.078e-2	7.429e-2
Taurine and hypotaurine metabolism	KEGG	1	GAD1	17	10	70.65	1.407e-2	8.695e-2
Synaptic adhesion-like molecules	Reactome	1	GRIN2A	21	10	57.19	1.735e-2	9.879e-2
Histidine metabolism	KEGG	1	ALDH7A1	22	10	54.59	1.817e-2	1.016e-1
Unblocking of NMDA receptors, glutamate binding and activation	Reactome	1	GRIN2A	22	10	54.59	1.817e-2	1.016e-1