# GeDiPNet Cluster 35 -- Top Shared Genes -- generated 2026-10-07 00:30:35
# Curated genes (disease_gdp) linked to 2 or more of this cluster's member diseases, most widely shared first. Data as of: 2026-10-07 03:15:01.
Gene	Member Diseases Linked	Cluster Size	Linked Diseases
GCK	11	17	Congenital hyperinsulinism; Hyperglycemia; Hyperinsulinemic hypoglycemia; Hyperinsulinism; Hypoglycemia; Maturity-onset diabetes of the young; Maturity-onset diabetes of the young (mody); monogenic diabetes; Neonatal diabetes mellitus; Permanent neonatal diabetes mellitus; Transient neonatal diabetes mellitus
ABCC8	10	17	Congenital hyperinsulinism; Hyperinsulinemic hypoglycemia; Hyperinsulinism; Hypoglycemia; Maturity-onset diabetes of the young; Maturity-onset diabetes of the young (mody); monogenic diabetes; Neonatal diabetes mellitus; Permanent neonatal diabetes mellitus; Transient neonatal diabetes mellitus
INS	10	17	Diabetic ketoacidosis; Hyperglycemia; Hyperinsulinism; Hypoglycemia; Maturity-onset diabetes of the young; Maturity-onset diabetes of the young (mody); monogenic diabetes; Neonatal diabetes mellitus; Permanent neonatal diabetes mellitus; Transient neonatal diabetes mellitus
KCNJ11	10	17	Congenital hyperinsulinism; Hyperinsulinemic hypoglycemia; Hyperinsulinism; Hypoglycemia; Maturity-onset diabetes of the young; Maturity-onset diabetes of the young (mody); monogenic diabetes; Neonatal diabetes mellitus; Permanent neonatal diabetes mellitus; Transient neonatal diabetes mellitus
HNF1A	6	17	Hyperglycemia; Hyperinsulinism; Hypoglycemia; Maturity-onset diabetes of the young; Maturity-onset diabetes of the young (mody); monogenic diabetes
HNF4A	6	17	Congenital hyperinsulinism; Hyperinsulinism; Hypoglycemia; Maturity-onset diabetes of the young; Maturity-onset diabetes of the young (mody); monogenic diabetes
INS-IGF2	6	17	Diabetic ketoacidosis; Hyperglycemia; Hypoglycemia; Maturity-onset diabetes of the young (mody); Neonatal diabetes mellitus; Permanent neonatal diabetes mellitus
PDX1	6	17	Hyperglycemia; Maturity-onset diabetes of the young; Maturity-onset diabetes of the young (mody); monogenic diabetes; Neonatal diabetes mellitus; Permanent neonatal diabetes mellitus
GLUD1	5	17	Congenital hyperinsulinism; Hyperinsulinemic hypoglycemia; Hyperinsulinism; Hyperinsulinism-hyperammonemia syndrome; Hypoglycemia
NEUROD1	5	17	Hyperglycemia; Maturity-onset diabetes of the young; Maturity-onset diabetes of the young (mody); monogenic diabetes; Permanent neonatal diabetes mellitus
SLC2A2	5	17	Diabetic ketoacidosis; Fanconi-bickel syndrome; Neonatal diabetes mellitus; Permanent neonatal diabetes mellitus; Transient neonatal diabetes mellitus
PAX4	4	17	Diabetic ketoacidosis; Hyperglycemia; Maturity-onset diabetes of the young; Maturity-onset diabetes of the young (mody)
CCL2	3	17	Carotid artery disease; Hyperglycemia; Hyperinsulinism
CD163	3	17	Carotid artery disease; Hyperglycemia; Hyperinsulinism
GATA4	3	17	Neonatal diabetes mellitus; Permanent neonatal diabetes mellitus; Transient neonatal diabetes mellitus
HADH	3	17	Congenital hyperinsulinism; Hyperinsulinemic hypoglycemia; Hyperinsulinism
HNF1B	3	17	Maturity-onset diabetes of the young (mody); Permanent neonatal diabetes mellitus; Transient neonatal diabetes mellitus
INSR	3	17	Hyperglycemia; Hyperinsulinemic hypoglycemia; Hyperinsulinism
KLF11	3	17	Hyperglycemia; Maturity-onset diabetes of the young; Maturity-onset diabetes of the young (mody)
AGT	2	17	Carotid artery disease; Hyperinsulinism
APPL1	2	17	Maturity-onset diabetes of the young; Maturity-onset diabetes of the young (mody)
BLK	2	17	Maturity-onset diabetes of the young; Maturity-onset diabetes of the young (mody)
CD40	2	17	Hyperglycemia; Hyperinsulinism
CEL	2	17	Maturity-onset diabetes of the young; Maturity-onset diabetes of the young (mody)
COL3A1	2	17	Hyperglycemia; Hyperinsulinism
CYP2C9	2	17	Hyperglycemia; Hypoglycemia
FBN1	2	17	Hyperglycemia; Hyperinsulinism
FCGR3B	2	17	Hyperglycemia; Hyperinsulinism
G6PC1	2	17	glycogen storage disease I; Hypoglycemia
GCG	2	17	Hyperglycemia; Hyperinsulinism
GPX1	2	17	Hyperglycemia; Hyperinsulinism
HMOX1	2	17	Carotid artery disease; Hyperinsulinism
IL6	2	17	Hyperglycemia; Hyperinsulinism
ITGAM	2	17	Hyperglycemia; Hyperinsulinism
LEP	2	17	Hyperglycemia; Hyperinsulinism
LEPR	2	17	Hyperglycemia; Hyperinsulinism
LTA	2	17	Carotid artery disease; Hyperinsulinism
MNX1	2	17	Neonatal diabetes mellitus; Permanent neonatal diabetes mellitus
MTTP	2	17	Abetalipoproteinemia; Hyperinsulinism
NOS3	2	17	Hyperglycemia; Hyperinsulinism
PTF1A	2	17	Maturity-onset diabetes of the young (mody); Permanent neonatal diabetes mellitus
RFX6	2	17	Maturity-onset diabetes of the young (mody); monogenic diabetes
SHLD2	2	17	Hyperinsulinemic hypoglycemia; Hyperinsulinism
SLC16A1	2	17	Hyperinsulinemic hypoglycemia; Hyperinsulinism
SOD2	2	17	Carotid artery disease; Hypoglycemia
TNF	2	17	Hyperinsulinism; Hypoglycemia
UCP2	2	17	Carotid artery disease; Hyperinsulinism