# GeDiPNet Cluster 347 -- Enriched Pathways -- generated 2026-10-08 19:30:54
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Transcriptional misregulation in cancer	KEGG	4	HMGA2, MDM2, DDIT3, FUS	198	9	26.96	8.465e-6	2.992e-4
Oncogene Induced Senescence	Reactome	2	CDK4, MDM2	33	9	80.88	2.604e-4	4.857e-3
Bladder cancer	KEGG	2	CDK4, MDM2	41	9	65.09	4.032e-4	6.891e-3
Melanoma	KEGG	2	CDK4, MDM2	73	9	36.56	1.276e-3	1.674e-2
p53 signaling pathway	KEGG	2	CDK4, MDM2	75	9	35.59	1.347e-3	1.742e-2
Glioma	KEGG	2	CDK4, MDM2	76	9	35.12	1.382e-3	1.777e-2
Chronic myeloid leukemia	KEGG	2	CDK4, MDM2	77	9	34.66	1.419e-3	1.813e-2
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4	Reactome	1	CDK4	2	9	667.22	1.498e-3	1.890e-2
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4	Reactome	1	CDK4	2	9	667.22	1.498e-3	1.890e-2
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	Reactome	1	CDK4	3	9	444.81	2.247e-3	2.539e-2
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	Reactome	1	CDK4	3	9	444.81	2.247e-3	2.539e-2
Endocrine resistance	KEGG	2	CDK4, MDM2	99	9	26.96	2.332e-3	2.608e-2
Oxidative Stress Induced Senescence	Reactome	2	CDK4, MDM2	125	9	21.35	3.688e-3	3.619e-2
PTK6 Regulates Cell Cycle	Reactome	1	CDK4	6	9	222.41	4.489e-3	4.138e-2
ChREBP activates metabolic gene expression	Reactome	1	FASN	7	9	190.63	5.235e-3	4.595e-2