# GeDiPNet Cluster 332 -- Enriched Pathways -- generated 2026-10-08 23:39:00
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Oxytocin signaling pathway	KEGG	2	RYR1, CACNA1S	154	2	77.99	1.634e-4	3.244e-3
Calcium signaling pathway	KEGG	2	RYR1, CACNA1S	254	2	47.28	4.456e-4	7.199e-3
Prion disease	KEGG	2	RYR1, CACNA1S	275	2	43.67	5.224e-4	8.143e-3
Pathways of neurodegeneration - multiple diseases	KEGG	2	RYR1, CACNA1S	480	2	25.02	1.594e-3	1.925e-2
Phase 2 - plateau phase	Reactome	1	CACNA1S	25	2	240.20	4.159e-3	3.858e-2
Phase 0 - rapid depolarisation	Reactome	1	CACNA1S	44	2	136.48	7.314e-3	5.640e-2
Ion homeostasis	Reactome	1	RYR1	54	2	111.20	8.973e-3	6.462e-2
Long-term depression	KEGG	1	RYR1	60	2	100.08	9.967e-3	6.894e-2
Cortisol synthesis and secretion	KEGG	1	CACNA1S	65	2	92.38	1.080e-2	7.277e-2
GnRH secretion	KEGG	1	CACNA1S	65	2	92.38	1.080e-2	7.277e-2
Renin secretion	KEGG	1	CACNA1S	69	2	87.03	1.146e-2	7.549e-2
Stimuli-sensing channels	Reactome	1	RYR1	79	2	76.01	1.311e-2	8.197e-2
Insulin secretion	KEGG	1	CACNA1S	86	2	69.83	1.427e-2	8.608e-2
Arrhythmogenic right ventricular cardiomyopathy	KEGG	1	CACNA1S	86	2	69.83	1.427e-2	8.608e-2
Cardiac muscle contraction	KEGG	1	CACNA1S	87	2	69.02	1.444e-2	8.676e-2