# GeDiPNet Cluster 330 -- Enriched Pathways -- generated 2026-10-07 17:18:16
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Wnt signaling pathway	KEGG	4	DKK1, MAP3K7, NKD1, FRZB	174	29	9.52	7.617e-4	1.107e-2
Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)	Reactome	1	SLC24A4	1	29	414.14	2.415e-3	2.621e-2
Toll Like Receptor 7/8 (TLR7/8) Cascade	Reactome	1	TLR8	2	29	207.07	4.824e-3	4.284e-2
Reelin signalling pathway	Reactome	1	VLDLR	5	29	82.83	1.202e-2	7.638e-2
VLDL clearance	Reactome	1	VLDLR	5	29	82.83	1.202e-2	7.638e-2
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	Reactome	1	DKK1	6	29	69.02	1.440e-2	8.517e-2
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	Reactome	1	DKK1	8	29	51.77	1.916e-2	1.003e-1
MyD88 dependent cascade initiated on endosome	Reactome	1	TLR8	8	29	51.77	1.916e-2	1.003e-1
IRAK2 mediated activation of TAK1 complex	Reactome	1	MAP3K7	10	29	41.41	2.389e-2	1.137e-1
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	Reactome	1	CTLA4	10	29	41.41	2.389e-2	1.137e-1
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	Reactome	1	TLR8	10	29	41.41	2.389e-2	1.137e-1
TICAM1,TRAF6-dependent induction of TAK1 complex	Reactome	1	MAP3K7	11	29	37.65	2.625e-2	1.197e-1
Alpha-protein kinase 1 signaling pathway	Reactome	1	MAP3K7	11	29	37.65	2.625e-2	1.197e-1
Transport of bile salts and organic acids, metal ions and amine compounds	Reactome	1	SLC14A1	11	29	37.65	2.625e-2	1.197e-1
Regulation of IFNG signaling	Reactome	1	SOCS1	11	29	37.65	2.625e-2	1.197e-1