# GeDiPNet Cluster 33 -- Enriched Pathways -- generated 2026-10-08 14:37:09
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Fluid shear stress and atherosclerosis	KEGG	14	GSTM1, MMP9, NOS3, GSTT1, MMP2, PLAT, TRPV4, PIK3CA, ACTB, ACVR1, MAPK14, TNF	141	177	6.74	1.934e-8	1.524e-6
Estrogen signaling pathway	KEGG	12	MMP9, NOS3, MMP2, ESR2, PIK3CA, SP1, ATF4, GNAS, POMC, OPRM1, TGFA, HSPA1B	139	177	5.86	9.490e-7	4.655e-5
Opioid Signalling	Reactome	3	PDYN, POMC, OPRM1	3	177	67.85	3.148e-6	1.316e-4
Lipid and atherosclerosis	KEGG	14	MMP9, NOS3, CYP1A1, PIK3CA, APOA1, ATF4, SOD2, ABCG1, PPARG, MAPK14, NLRP3, TNF	216	177	4.40	3.681e-6	1.500e-4
Prostate cancer	KEGG	9	MMP9, PLAT, AR, PIK3CA, SRD5A2, ATF4, TGFA, GSTP1, TCF7L2	98	177	6.23	1.366e-5	4.420e-4
Pathways in cancer	KEGG	21	GSTM1, HGF, MMP9, F2, GSTT1, IL23R, MMP2, AR, ESR2, HHIP, PIK3CA, SP1	533	177	2.67	3.755e-5	1.023e-3
Hepatocellular carcinoma	KEGG	11	GSTM1, HGF, GSTT1, PIK3CA, WNT11, WNT8A, ACTB, TXNRD2, TGFA, GSTP1, TCF7L2	170	177	4.39	4.243e-5	1.136e-3
Hormone signaling	KEGG	12	ESR2, PIK3CA, GNAS, NOS1, NPPA, PDYN, POMC, OPRM1, ACVR1, ADIPOQ, GHRH, ADRA2A	219	177	3.72	9.604e-5	2.197e-3
Interleukin-4 and Interleukin-13 signaling	Reactome	8	HGF, MMP9, IL23R, MMP2, POMC, OPRM1, IL17A, TNF	108	177	5.03	1.910e-4	3.812e-3
Extra-nuclear estrogen signaling	Reactome	6	MMP9, NOS3, MMP2, ESR2, PIK3CA, TGFA	58	177	7.02	2.019e-4	3.968e-3
HDL remodeling	Reactome	3	APOE, APOA1, ABCG1	10	177	20.36	3.500e-4	6.157e-3
Glutathione conjugation	Reactome	4	GSTM1, GSTT1, ESD, GSTP1	24	177	11.31	3.848e-4	6.629e-3
Androgen biosynthesis	Reactome	3	HSD3B2, SRD5A2, POMC	11	177	18.51	4.760e-4	7.850e-3
Endocrine resistance	KEGG	7	MMP9, MMP2, ESR2, PIK3CA, SP1, GNAS, MAPK14	99	177	4.80	6.388e-4	9.852e-3
Response of EIF2AK1 (HRI) to heme deficiency	Reactome	2	ATF3, ATF4	3	177	45.24	6.417e-4	9.886e-3