# GeDiPNet Cluster 328 -- Enriched Pathways -- generated 2026-10-08 17:59:03
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Vascular smooth muscle contraction	KEGG	4	MYH9, PPP1R12B, AGT, NPPA	134	17	21.09	3.151e-5	8.844e-4
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	Reactome	2	CYP2C8, CYP2J2	8	17	176.62	5.254e-5	1.347e-3
Lipid and atherosclerosis	KEGG	4	NLRP3, CYP2C8, CYP2J2, HSPA8	216	17	13.08	2.015e-4	3.965e-3
Hormone signaling	KEGG	4	AGTR2, STAT5A, AGT, NPPA	219	17	12.90	2.124e-4	4.127e-3
Renin-angiotensin system	KEGG	2	AGTR2, AGT	23	17	61.43	4.689e-4	7.750e-3
RHO GTPases activate PAKs	Reactome	2	MYH9, PPP1R12B	23	17	61.43	4.689e-4	7.750e-3
Xenobiotics	Reactome	2	CYP2C8, CYP2J2	24	17	58.87	5.111e-4	8.260e-3
Linoleic acid metabolism	KEGG	2	CYP2C8, CYP2J2	30	17	47.10	8.015e-4	1.176e-2
Pathogenic Escherichia coli infection	KEGG	3	MYH9, NLRP3, MYO6	200	17	10.60	2.604e-3	2.836e-2
Signaling by Leptin	Reactome	1	STAT5A	2	17	353.24	2.829e-3	3.003e-2
Arachidonic acid metabolism	KEGG	2	CYP2C8, CYP2J2	63	17	22.43	3.501e-3	3.480e-2
Renin secretion	KEGG	2	AGT, NPPA	69	17	20.48	4.184e-3	3.943e-2
Aldosterone synthesis and secretion	KEGG	2	AGT, NPPA	98	17	14.42	8.276e-3	6.219e-2
Biosynthesis of maresin-like SPMs	Reactome	1	CYP2C8	6	17	117.75	8.465e-3	6.313e-2
AGE-RAGE signaling pathway in diabetic complications	KEGG	2	STAT5A, AGT	101	17	13.99	8.771e-3	6.464e-2