# GeDiPNet Cluster 325 -- Enriched Pathways -- generated 2026-10-09 22:58:45
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-10 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Hormone signaling	KEGG	8	DRD2, GNRH1, LHB, PRL, PRLR, DRD3, OXTR, INS	219	15	29.25	6.205e-11	9.476e-9
Neuroactive ligand-receptor interaction	KEGG	7	DRD2, GNRH1, LHB, PRL, PRLR, DRD3, OXTR	370	15	15.15	1.294e-7	8.785e-6
Prolactin signaling pathway	KEGG	4	LHB, PRL, PRLR, INS	71	15	45.11	1.457e-6	7.271e-5
Dopamine receptors	Reactome	2	DRD2, DRD3	5	15	320.27	1.453e-5	4.827e-4
Hormone ligand-binding receptors	Reactome	2	GNRH1, LHB	12	15	133.44	9.541e-5	2.232e-3
Prolactin receptor signaling	Reactome	2	PRL, PRLR	12	15	133.44	9.541e-5	2.232e-3
Growth hormone receptor signaling	Reactome	2	PRL, PRLR	14	15	114.38	1.314e-4	2.881e-3
Type I diabetes mellitus	KEGG	2	GAD1, INS	44	15	36.39	1.336e-3	1.754e-2
Cocaine addiction	KEGG	2	DRD2, FOSB	49	15	32.68	1.655e-3	2.067e-2
Ovarian steroidogenesis	KEGG	2	LHB, INS	52	15	30.79	1.862e-3	2.252e-2
GABA synthesis	Reactome	1	GAD1	2	15	400.33	2.496e-3	2.775e-2
Signaling by Insulin receptor	Reactome	1	INS	2	15	400.33	2.496e-3	2.775e-2
cAMP signaling pathway	KEGG	3	DRD2, LHB, OXTR	226	15	10.63	2.531e-3	2.801e-2
GnRH secretion	KEGG	2	GNRH1, LHB	65	15	24.64	2.894e-3	3.079e-2
GnRH signaling pathway	KEGG	2	GNRH1, LHB	93	15	17.22	5.833e-3	5.020e-2