# GeDiPNet Cluster 32 -- Enriched Pathways -- generated 2026-10-09 15:55:28
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Ovarian steroidogenesis	KEGG	9	CYP17A1, CYP1A1, FSHB, LHB, LHCGR, BMP15, BMP6, CYP19A1, SCARB1	52	404	5.15	5.142e-5	1.269e-3
Prolactin signaling pathway	KEGG	10	CYP17A1, ESR1, LHB, LHCGR, ESR2, MAP2K1, SOS1, GALT, JAK2, PRLR	71	404	4.19	1.224e-4	2.567e-3
Sperm Motility And Taxes	Reactome	4	CATSPER1, CATSPER2, CATSPERB, KCNU1	9	404	13.21	1.390e-4	2.842e-3
Hormone ligand-binding receptors	Reactome	4	FSHB, GNRH1, LHB, LHCGR	12	404	9.91	5.037e-4	7.913e-3
Chronic myeloid leukemia	KEGG	9	BAX, CBL, MDM2, TP53, MAP2K1, PTPN11, SOS1, MECOM, MYC	77	404	3.47	1.076e-3	1.420e-2
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE	Reactome	2	MTR, MTRR	2	404	29.73	1.129e-3	1.473e-2
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG	Reactome	2	MTR, MTRR	2	404	29.73	1.129e-3	1.473e-2
SUMOylation of intracellular receptors	Reactome	5	AR, ESR1, NR1H4, NR5A1, NR5A2	27	404	5.51	1.839e-3	2.145e-2
Motor proteins	KEGG	15	DNAH1, DNAH17, DNAH10, DNAH11, DNAH3, DNAH5, DNAI1, MYO6, DNAH6, DNAH7, TUBB3, DNAH12	194	404	2.30	2.334e-3	2.549e-2
GLI proteins bind promoters of Hh responsive genes to promote transcription	Reactome	2	GLI2, GLI1	3	404	19.82	3.311e-3	3.286e-2
MAPK3 (ERK1) activation	Reactome	3	MAP2K1, PTPN11, JAK2	10	404	8.92	3.801e-3	3.621e-2
Huntington disease	KEGG	20	DNAH1, DNAH17, BAX, SOD2, TP53, DNAH10, DNAH11, DNAH3, DNAH5, DNAI1, DNAH6, DNAH7	308	404	1.93	3.833e-3	3.643e-2
Autophagy - other	KEGG	5	ATG2A, ATG7, ATG9B, ATG4D, ATG5	32	404	4.64	3.998e-3	3.753e-2
Stabilization of p53	Reactome	3	MDM2, TP53, CHEK2	11	404	8.11	5.096e-3	4.429e-2
Interleukin-6 signaling	Reactome	3	CBL, PTPN11, JAK2	11	404	8.11	5.096e-3	4.429e-2