# GeDiPNet Cluster 319 -- Enriched Pathways -- generated 2026-10-10 05:06:39
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-10 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Bile secretion	KEGG	9	ABCB11, ABCB4, ABCB1, ABCG8, CYP7A1, NR1H4, SLC10A1, SULT2A1, SLC51A	90	34	35.32	2.227e-12	4.543e-10
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Reactome	4	ABCB11, HSD3B7, CYP7A1, NR1H4	24	34	58.87	5.464e-7	3.067e-5
ABC transporters	KEGG	4	ABCB11, ABCB4, ABCB1, ABCG8	45	34	31.40	7.347e-6	2.767e-4
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	Reactome	3	HSD3B7, CYP7A1, NR1H4	15	34	70.65	9.216e-6	3.326e-4
Recycling of bile acids and salts	Reactome	3	ABCB11, NR1H4, SLC10A1	16	34	66.23	1.132e-5	3.928e-4
PPARA activates gene expression	Reactome	4	ABCB4, CYP7A1, NR1H4, SULT2A1	115	34	12.29	2.964e-4	5.470e-3
Cholesterol metabolism	KEGG	3	ABCB11, ABCG8, CYP7A1	51	34	20.78	3.934e-4	6.858e-3
Synthesis of bile acids and bile salts	Reactome	2	CYP7A1, NR1H4	14	34	50.46	6.930e-4	1.063e-2
Primary bile acid biosynthesis	KEGG	2	HSD3B7, CYP7A1	17	34	41.56	1.030e-3	1.439e-2
Endogenous sterols	Reactome	2	CYP7A1, NR1H4	25	34	28.26	2.240e-3	2.577e-2
MPS IV - Morquio syndrome B	Reactome	1	GLB1	1	34	353.24	2.831e-3	3.033e-2
Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1	Reactome	1	ABCB4	1	34	353.24	2.831e-3	3.033e-2
Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2	Reactome	1	ABCB11	1	34	353.24	2.831e-3	3.033e-2
AGE-RAGE signaling pathway in diabetic complications	KEGG	3	EGR1, TNF, VCAM1	101	34	10.49	2.859e-3	3.052e-2
African trypanosomiasis	KEGG	2	TNF, VCAM1	37	34	19.09	4.869e-3	4.453e-2