# GeDiPNet Cluster 317 -- Enriched Pathways -- generated 2026-10-08 03:20:12
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
IL-6-type cytokine receptor ligand interactions	Reactome	2	LIFR, IL6ST	17	9	156.99	6.750e-5	1.647e-3
Anchoring of the basal body to the plasma membrane	Reactome	2	CC2D2A, CEP290	98	9	27.23	2.286e-3	2.572e-2
RUNX1 regulates transcription of genes involved in interleukin signaling	Reactome	1	LIFR	5	9	266.89	3.742e-3	3.650e-2
Signaling pathways regulating pluripotency of stem cells	KEGG	2	LIFR, IL6ST	144	9	18.53	4.864e-3	4.373e-2
JAK-STAT signaling pathway	KEGG	2	LIFR, IL6ST	168	9	15.89	6.565e-3	5.367e-2
MAPK1 (ERK2) activation	Reactome	1	IL6ST	9	9	148.27	6.726e-3	5.441e-2
MAPK3 (ERK1) activation	Reactome	1	IL6ST	10	9	133.44	7.471e-3	5.806e-2
Interleukin-27 signaling	Reactome	1	IL6ST	11	9	121.31	8.216e-3	6.202e-2
Interleukin-6 signaling	Reactome	1	IL6ST	11	9	121.31	8.216e-3	6.202e-2
Interleukin-35 Signalling	Reactome	1	IL6ST	12	9	111.20	8.960e-3	6.534e-2
Defective EXT2 causes exostoses 2	Reactome	1	HSPG2	14	9	95.32	1.045e-2	7.203e-2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	Reactome	1	HSPG2	14	9	95.32	1.045e-2	7.203e-2
Defective B4GALT7 causes EDS, progeroid type	Reactome	1	HSPG2	20	9	66.72	1.489e-2	8.912e-2
Defective B3GAT3 causes JDSSDHD	Reactome	1	HSPG2	20	9	66.72	1.489e-2	8.912e-2
Defective B3GALT6 causes EDSP2 and SEMDJL1	Reactome	1	HSPG2	20	9	66.72	1.489e-2	8.912e-2