# GeDiPNet Cluster 309 -- Enriched Pathways -- generated 2026-10-07 01:36:03
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Autoimmune thyroid disease	KEGG	24	TSHR, CD40, CD40LG, CTLA4, HLA-B, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, IL10, IL2	54	256	20.85	2.079e-26	4.416e-23
Allograft rejection	KEGG	21	CD40, CD40LG, HLA-B, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, IFNG, IL10, IL2, IL4	39	256	25.26	1.553e-25	2.958e-22
Inflammatory bowel disease	KEGG	25	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, IFNG, IL10, IL13, IL17A, IL1B, IL2, IL23R	66	256	17.77	2.453e-25	4.515e-22
Type I diabetes mellitus	KEGG	20	HLA-B, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, IFNG, IL1B, IL2, LTA, TNF, HLA-C	44	256	21.32	1.988e-22	2.467e-19
Graft-versus-host disease	KEGG	20	HLA-B, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, IFNG, IL1B, IL2, IL6, TNF, HLA-C	45	256	20.85	3.511e-22	4.215e-19
Rheumatoid arthritis	KEGG	25	CTLA4, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, ICAM1, IFNG, IL17A, IL1B, IL6, TGFB1	95	256	12.35	7.544e-21	6.830e-18
Asthma	KEGG	15	CD40, CD40LG, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, IL10, IL13, IL3, IL4, TNF	32	256	21.99	2.317e-17	1.174e-14
Th17 cell differentiation	KEGG	23	CD4, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, IFNG, IL17A, IL1B, IL2, IL23R, IL2RA	109	256	9.90	6.108e-17	2.870e-14
Intestinal immune network for IgA production	KEGG	17	CD40, CD40LG, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, ICOS, IL10, IL2, IL4, IL6	50	256	15.95	1.196e-16	5.306e-14
Herpes simplex virus 1 infection	KEGG	25	HLA-B, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, IFIH1, IFNG, IL1B, IL6, LTA, TNF	182	256	6.44	9.606e-14	2.485e-11
Interleukin-4 and Interleukin-13 signaling	Reactome	20	ICAM1, IL10, IL13, IL17A, IL1B, IL23R, IL4, IL6, IL6R, TGFB1, TNF, TP53	108	256	8.69	9.848e-14	2.531e-11
Phosphorylation of CD3 and TCR zeta chains	Reactome	11	CD4, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, PTPN22, HLA-DPB1, HLA-DRA, HLA-DRB5, PTPRC	22	256	23.46	1.911e-13	4.598e-11
Hematopoietic cell lineage	KEGG	19	CD4, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, IL1B, IL2RA, IL3, IL4, IL6, IL6R	100	256	8.91	2.560e-13	6.080e-11
Leishmaniasis	KEGG	17	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, IFNG, IL10, IL1B, IL4, TGFB1, TNF, HLA-DPB1	78	256	10.22	4.474e-13	1.025e-10
Translocation of ZAP-70 to Immunological synapse	Reactome	10	CD4, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, PTPN22, HLA-DPB1, HLA-DRA, HLA-DRB5	19	256	24.69	1.269e-12	2.721e-10