# GeDiPNet Cluster 307 -- Enriched Pathways -- generated 2026-10-07 22:11:10
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
JAK-STAT signaling pathway	KEGG	6	MPL, THPO, JAK2, IFNA2, PDGFA, PDGFB	168	15	28.60	3.090e-8	2.310e-6
PI3K-Akt signaling pathway	KEGG	7	JAK2, TP53, FGF2, IFNA2, PDGFA, PDGFB, VWF	361	15	15.53	1.094e-7	7.075e-6
Interleukin-4 and Interleukin-13 signaling	Reactome	5	JAK2, TP53, FGF2, TGFB1, IL1B	108	15	37.07	1.498e-7	9.367e-6
MAPK signaling pathway	KEGG	6	TP53, FGF2, PDGFA, PDGFB, TGFB1, IL1B	299	15	16.07	9.382e-7	4.606e-5
Pathways in cancer	KEGG	7	JAK2, TP53, FGF2, IFNA2, PDGFA, PDGFB, TGFB1	533	15	10.52	1.538e-6	7.044e-5
Melanoma	KEGG	4	TP53, FGF2, PDGFA, PDGFB	73	15	43.87	1.630e-6	7.412e-5
Herpes simplex virus 1 infection	KEGG	5	CALR, JAK2, TP53, IFNA2, IL1B	182	15	22.00	2.009e-6	8.915e-5
EGFR tyrosine kinase inhibitor resistance	KEGG	4	JAK2, FGF2, PDGFA, PDGFB	80	15	40.03	2.356e-6	1.024e-4
Kaposi sarcoma-associated herpesvirus infection	KEGG	5	JAK2, TP53, FGF2, IFNA2, PDGFB	196	15	20.43	2.892e-6	1.221e-4
Non-integrin membrane-ECM interactions	Reactome	3	FGF2, PDGFA, PDGFB	24	15	100.08	3.141e-6	1.314e-4
Platelet degranulation 	Reactome	4	PDGFA, PDGFB, TGFB1, VWF	123	15	26.04	1.310e-5	4.268e-4
RAF/MAP kinase cascade	Reactome	4	JAK2, FGF2, PDGFA, PDGFB	124	15	25.83	1.353e-5	4.390e-4
Cytokine-cytokine receptor interaction	KEGG	5	MPL, THPO, IFNA2, TGFB1, IL1B	298	15	13.43	2.226e-5	6.661e-4
Fluid shear stress and atherosclerosis	KEGG	4	TP53, PDGFA, PDGFB, IL1B	141	15	22.71	2.247e-5	6.714e-4
RUNX3 regulates CDKN1A transcription	Reactome	2	TP53, TGFB1	7	15	228.76	3.047e-5	8.600e-4