# GeDiPNet Cluster 303 -- Enriched Pathways -- generated 2026-10-07 00:45:13
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Proteoglycans in cancer	KEGG	18	WNT1, ESR1, FGF2, MMP2, ANK1, IGF2, TGFB2, IGF1, FZD7, ITGA2, ITGB3, WNT16	204	221	4.80	3.855e-8	2.827e-6
Wnt signaling pathway	KEGG	15	AXIN1, RSPO3, SFRP4, TCF7L2, WNT1, FZD7, LRP5, NFATC1, SOST, WNT16, NFATC2, RSPO2	174	221	4.68	7.348e-7	3.728e-5
RUNX1 regulates transcription of genes involved in WNT signaling	Reactome	4	AXIN1, RSPO3, ESR1, CBFB	6	221	36.23	1.626e-6	7.398e-5
Breast cancer	KEGG	13	AXIN1, TCF7L2, WNT1, ESR1, FGF2, JAG1, IGF1, FZD7, LRP5, WNT16, MTOR, WNT2	148	221	4.77	3.331e-6	1.354e-4
Gastric cancer	KEGG	13	AXIN1, TCF7L2, WNT1, FGF2, TGFBR2, TGFB2, FZD7, LRP5, WNT16, FGFR2, MTOR, WNT2	150	221	4.71	3.868e-6	1.543e-4
Pathways in cancer	KEGG	26	ABL1, AXIN1, TCF7L2, WNT1, BMP2, CDKN2A, ESR1, FGF2, JAG1, MMP2, TGFBR2, CHUK	533	221	2.65	5.349e-6	2.005e-4
Signaling pathways regulating pluripotency of stem cells	KEGG	12	AXIN1, WNT1, FGF2, BMPR1B, DLX5, ZIC3, IGF1, FZD7, WNT16, FGFR2, WNT2, WNT7B	144	221	4.53	1.370e-5	4.360e-4
Hepatocellular carcinoma	KEGG	13	AXIN1, TCF7L2, WNT1, CDKN2A, TGFBR2, IGF2, TGFB2, FZD7, LRP5, WNT16, MTOR, WNT2	170	221	4.16	1.519e-5	4.760e-4
Basal cell carcinoma	KEGG	8	AXIN1, TCF7L2, WNT1, BMP2, FZD7, WNT16, WNT2, WNT7B	63	221	6.90	1.878e-5	5.698e-4
Hippo signaling pathway	KEGG	12	AXIN1, TCF7L2, WNT1, BMP2, TGFBR2, BMPR1B, TGFB2, FZD7, WNT16, LIMD1, WNT2, WNT7B	157	221	4.15	3.261e-5	8.955e-4
Human papillomavirus infection	KEGG	18	AXIN1, HLA-B, TCF7L2, WNT1, JAG1, CHUK, FZD7, ITGA2, ITGB3, WNT16, IRF1, ITGA11	333	221	2.94	4.348e-5	1.141e-3
RUNX1 regulates estrogen receptor mediated transcription	Reactome	3	AXIN1, ESR1, CBFB	6	221	27.17	1.180e-4	2.560e-3
VEGFA-VEGFR2 Pathway	Reactome	7	PTK2B, ITGB3, ELMO1, KDR, PTK2, PXN, WASF3	62	221	6.14	1.353e-4	2.861e-3
Endocrine resistance	KEGG	8	CDKN2A, ESR1, JAG1, MMP2, IGF1, ADCY4, MTOR, PTK2	99	221	4.39	4.714e-4	7.619e-3
Cushing syndrome	KEGG	10	AXIN1, TCF7L2, WNT1, AHR, CDKN2A, FZD7, WNT16, ADCY4, WNT2, WNT7B	155	221	3.51	5.837e-4	8.992e-3