# GeDiPNet Cluster 299 -- Enriched Pathways -- generated 2026-10-08 21:01:26
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Apoptotic cleavage of cell adhesion  proteins	Reactome	2	DSG1, DSP	11	17	128.45	1.029e-4	2.329e-3
Formation of ATP by chemiosmotic coupling	Reactome	2	ATP6, ATP8	18	17	78.50	2.847e-4	5.220e-3
Cristae formation	Reactome	2	ATP6, ATP8	18	17	78.50	2.847e-4	5.220e-3
Formation of the cornified envelope	Reactome	3	DSG1, DSP, KRT1	130	17	16.30	7.541e-4	1.121e-2
Keratinization	Reactome	3	DSG1, DSP, KRT1	152	17	13.94	1.186e-3	1.580e-2
Defective SLC2A10 causes arterial tortuosity syndrome (ATS)	Reactome	1	SLC2A10	1	17	706.47	1.415e-3	1.811e-2
Prion disease	KEGG	3	ATP6, ATP8, NOTCH1	275	17	7.71	6.365e-3	5.244e-2
Defective LFNG causes SCDO3	Reactome	1	NOTCH1	5	17	141.29	7.059e-3	5.613e-2
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	Reactome	1	NOTCH1	5	17	141.29	7.059e-3	5.613e-2
Pre-NOTCH Processing in Golgi	Reactome	1	NOTCH1	6	17	117.75	8.465e-3	6.313e-2
RUNX2 regulates bone development	Reactome	1	SMAD6	7	17	100.92	9.869e-3	6.949e-2
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	Reactome	1	NOTCH1	7	17	100.92	9.869e-3	6.949e-2
IRAK2 mediated activation of TAK1 complex	Reactome	1	TAB2	10	17	70.65	1.407e-2	8.603e-2
Activated NOTCH1 Transmits Signal to the Nucleus	Reactome	1	NOTCH1	10	17	70.65	1.407e-2	8.603e-2
TICAM1,TRAF6-dependent induction of TAK1 complex	Reactome	1	TAB2	11	17	64.22	1.547e-2	9.134e-2