# GeDiPNet Cluster 297 -- Enriched Pathways -- generated 2026-10-08 09:50:03
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Cholesterol metabolism	KEGG	3	APOC3, CETP, SCARB1	51	16	44.15	3.886e-5	1.052e-3
HDL remodeling	Reactome	2	APOC3, CETP	10	16	150.13	7.442e-5	1.780e-3
Notch-HLH transcription pathway	Reactome	2	NOTCH2, NCOR2	28	16	53.62	6.164e-4	9.576e-3
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Reactome	2	CETP, NCOR2	37	16	40.57	1.079e-3	1.472e-2
Notch signaling pathway	KEGG	2	NOTCH2, NCOR2	62	16	24.21	3.003e-3	3.119e-2
LDL remodeling	Reactome	1	CETP	3	16	250.21	3.992e-3	3.823e-2
NOTCH2 Activation and Transmission of Signal to the Nucleus	Reactome	1	NOTCH2	3	16	250.21	3.992e-3	3.823e-2
HDL clearance	Reactome	1	SCARB1	5	16	150.13	6.644e-3	5.398e-2
Scavenging by Class B Receptors	Reactome	1	SCARB1	5	16	150.13	6.644e-3	5.398e-2
Defective LFNG causes SCDO3	Reactome	1	NOTCH2	5	16	150.13	6.644e-3	5.398e-2
Pre-NOTCH Processing in Golgi	Reactome	1	NOTCH2	6	16	125.10	7.968e-3	6.070e-2
NOTCH2 intracellular domain regulates transcription	Reactome	1	NOTCH2	7	16	107.23	9.291e-3	6.693e-2
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	Reactome	1	NCOR2	9	16	83.40	1.193e-2	7.793e-2
Chylomicron remodeling	Reactome	1	APOC3	9	16	83.40	1.193e-2	7.793e-2
Chylomicron assembly	Reactome	1	APOC3	9	16	83.40	1.193e-2	7.793e-2