# GeDiPNet Cluster 292 -- Enriched Pathways -- generated 2026-10-08 20:19:37
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Cholesterol metabolism	KEGG	19	APOC2, ABCG5, ABCG8, APOB, APOE, LCAT, LDLR, LDLRAP1, PCSK9, ABCA1, CYP7A1, LPA	51	99	45.20	1.611e-27	3.575e-24
Chylomicron remodeling	Reactome	9	APOC2, APOB, APOE, APOA5, LPL, APOA1, APOA2, APOC3, GPIHBP1	9	99	121.31	1.212e-19	7.957e-17
Lipid and atherosclerosis	KEGG	21	APOB, HSPD1, ICAM1, IL1B, LDLR, MMP1, MMP3, MMP9, NFKBIA, NOS3, TLR4, TNFSF10	216	99	11.79	3.991e-17	1.717e-14
Chylomicron assembly	Reactome	7	APOC2, APOB, APOE, APOA1, APOA2, APOC3, MTTP	9	99	94.35	7.407e-14	1.855e-11
Chylomicron clearance	Reactome	5	APOB, APOE, LDLR, LDLRAP1, LIPC	5	99	121.31	3.438e-11	5.247e-9
HDL remodeling	Reactome	6	APOC2, APOE, LCAT, APOA1, APOC3, CETP	10	99	72.79	5.504e-11	7.932e-9
Interleukin-4 and Interleukin-13 signaling	Reactome	12	ALOX5, F13A1, ICAM1, IL10, IL1B, MMP1, MMP2, MMP3, MMP9, PTGS2, VCAM1, CCL2	108	99	13.48	7.227e-11	1.020e-8
Retinoid metabolism and transport	Reactome	8	APOC2, APOB, APOE, LPL, APOA1, APOA2, APOC3, GPIHBP1	41	99	23.67	1.222e-9	1.271e-7
Fluid shear stress and atherosclerosis	KEGG	12	GSTA4, ICAM1, IL1B, MMP2, MMP9, NOS3, VCAM1, EDN1, NCF1, NOX1, SELE, CCL2	141	99	10.32	1.653e-9	1.682e-7
AGE-RAGE signaling pathway in diabetic complications	KEGG	10	ICAM1, IL1B, MMP2, NOS3, VCAM1, COL3A1, EDN1, NOX1, SELE, CCL2	101	99	12.01	9.430e-9	8.018e-7
TNF signaling pathway	KEGG	10	ICAM1, IL1B, MMP3, MMP9, NFKBIA, PTGS2, VCAM1, EDN1, SELE, CCL2	119	99	10.19	4.623e-8	3.307e-6
Bile secretion	KEGG	9	ABCG5, ABCG8, LDLR, BAAT, EPHX1, SLC10A1, CYP7A1, HMGCR, ABCB1	90	99	12.13	4.945e-8	3.513e-6
Fat digestion and absorption	KEGG	7	ABCG5, ABCG8, APOB, ABCA1, APOA1, APOA4, MTTP	43	99	19.75	5.275e-8	3.714e-6
Malaria	KEGG	7	ICAM1, IL10, IL1B, TLR4, VCAM1, SELE, CCL2	50	99	16.98	1.560e-7	9.697e-6
PPAR signaling pathway	KEGG	8	MMP1, APOA5, CYP7A1, LPL, APOA1, APOA2, APOC3, PPARA	76	99	12.77	1.903e-7	1.150e-5