# GeDiPNet Cluster 289 -- Enriched Pathways -- generated 2026-10-07 08:44:35
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
AGE-RAGE signaling pathway in diabetic complications	KEGG	13	IL1B, TGFB1, IL6, TNF, COL1A1, MAPK1, MAPK3, MAPK8, MAPK9, ICAM1, NOS3, TGFBR1	101	58	26.65	1.097e-15	4.221e-13
Th17 cell differentiation	KEGG	12	IL1B, TGFB1, HLA-DPB1, HLA-DRB1, IL2RA, IL6, FOS, MAPK1, MAPK3, MAPK8, MAPK9, TGFBR1	109	58	22.80	1.059e-13	2.694e-11
Rheumatoid arthritis	KEGG	11	IL1B, TGFB1, CD28, HLA-DPB1, HLA-DRB1, IL6, TNF, FOS, FLT1, ICAM1, PTH	95	58	23.98	7.024e-13	1.580e-10
Chagas disease	KEGG	11	IL1B, TGFB1, ACE, IL6, TNF, FOS, MAPK1, MAPK3, MAPK8, MAPK9, TGFBR1	103	58	22.11	1.743e-12	3.653e-10
Human T-cell leukemia virus 1 infection	KEGG	13	TGFB1, HLA-DPB1, HLA-DRB1, IL2RA, IL6, TNF, FOS, MAPK1, MAPK3, MAPK8, MAPK9, ICAM1	224	58	12.02	3.509e-11	5.593e-9
Tuberculosis	KEGG	12	CD14, IL1B, TGFB1, HLA-DPB1, HLA-DRB1, IL6, TNF, MAPK1, MAPK3, MAPK8, MAPK9, VDR	181	58	13.73	4.645e-11	7.226e-9
Toll-like receptor signaling pathway	KEGG	10	CD14, IL1B, IL6, TNF, FOS, MAPK1, MAPK3, MAPK8, MAPK9, SPP1	109	58	19.00	9.041e-11	1.313e-8
Pertussis	KEGG	9	CD14, IL1B, IL6, TNF, FOS, MAPK1, MAPK3, MAPK8, MAPK9	78	58	23.89	1.054e-10	1.508e-8
Focal adhesion	KEGG	12	COL1A1, COL9A3, THBS2, COL9A2, MAPK1, MAPK3, MAPK8, MAPK9, PRKCG, FLT1, KDR, SPP1	203	58	12.24	1.772e-10	2.431e-8
TNF signaling pathway	KEGG	10	IL1B, IL6, TNF, FOS, MAPK1, MAPK3, MAPK8, MAPK9, ICAM1, VCAM1	119	58	17.40	2.175e-10	2.906e-8
Lipid and atherosclerosis	KEGG	12	CD14, IL1B, IL6, TNF, FOS, MAPK1, MAPK3, MAPK8, MAPK9, ICAM1, NOS3, VCAM1	216	58	11.50	3.636e-10	4.585e-8
Activation of the AP-1 family of transcription factors	Reactome	5	FOS, MAPK1, MAPK3, MAPK8, MAPK9	10	58	103.53	5.449e-10	6.555e-8
PI3K-Akt signaling pathway	KEGG	14	IL2RA, IL6, COL1A1, COL9A3, THBS2, COL9A2, MAPK1, MAPK3, EPO, FLT1, KDR, NOS3	361	58	8.03	1.169e-9	1.282e-7
Osteoclast differentiation	KEGG	10	IL1B, TGFB1, TNF, FOS, MAPK1, MAPK3, MAPK8, MAPK9, TGFBR1, TNFRSF11B	142	58	14.58	1.248e-9	1.356e-7
MAPK signaling pathway	KEGG	13	CD14, IL1B, TGFB1, TNF, FOS, MAPK1, MAPK3, MAPK8, MAPK9, PRKCG, FLT1, KDR	299	58	9.00	1.258e-9	1.363e-7