# GeDiPNet Cluster 288 -- Top Shared Genes -- generated 2026-10-07 12:02:02
# Curated genes (disease_gdp) linked to 2 or more of this cluster's member diseases, most widely shared first. Data as of: 2026-10-07 03:15:01.
Gene	Member Diseases Linked	Cluster Size	Linked Diseases
ABCB4	5	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
ABCC2	4	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis; Nonalcoholic fatty liver disease
CD3D	4	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis; Liver disease
HLA-DQA1	4	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis; Nonalcoholic fatty liver disease
NFE2L2	4	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis; Nonalcoholic fatty liver disease
NFKB1	4	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis; Liver disease
NOS2	4	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis; Liver disease
TGFB1	4	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis; Nonalcoholic fatty liver disease
ABCG2	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
AHR	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
ALB	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
ALDH2	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
APOC1	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
APOE	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
ATG5	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
CCL5	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
CD80	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
CDH5	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
CENPB	3	6	Biliary cholangitis; Biliary cirrhosis; Inner ear disease
CLEC16A	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
CXCL10	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
CXCL9	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
CXCR5	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
CYGB	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
CYP1A2	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
CYP2E1	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
DENND1B	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
ENTPD2	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
EXOC3L4	3	6	Biliary cholangitis; Biliary cirrhosis; Nonalcoholic fatty liver disease
GSTT1	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
HFE	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
HIF1A	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
HLA-DPB1	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
HLA-DQB1	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
IFNL4	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
IGFBP1	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
IL12A	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
IL12B	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
IL7R	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
KEAP1	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
KHDRBS3	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
KLHL8	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
KRT7	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
LOX	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
LOXL2	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
MAPK14	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
MMEL1	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
MTARC1	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
MTHFR	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
NOS3	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
NSA2	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
PNPLA3	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
RELA	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
SERPINA1	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
SERPINA2	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
SLC4A2	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
SLC51A	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
SLC51B	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
SPIB	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
ST8SIA1	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
STAT4	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
TM6SF2	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
TNF	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
TNFRSF1A	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
TRIB1	3	6	Liver cirrhosis; Liver disease; Nonalcoholic fatty liver disease
TYK2	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
UBD	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
UGT3A1	3	6	Biliary cholangitis; Biliary cirrhosis; Liver disease
VDR	3	6	Biliary cholangitis; Biliary cirrhosis; Liver cirrhosis
ABCB11	2	6	Liver cirrhosis; Liver disease
ACE	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
ACTA2	2	6	Liver cirrhosis; Liver disease
AKNA	2	6	Liver disease; Nonalcoholic fatty liver disease
ALAD	2	6	Liver cirrhosis; Liver disease
ALDH1A1	2	6	Liver disease; Nonalcoholic fatty liver disease
ANP32B	2	6	Biliary cholangitis; Biliary cirrhosis
ARID3A	2	6	Biliary cholangitis; Biliary cirrhosis
ARL14	2	6	Biliary cholangitis; Biliary cirrhosis
ATP7B	2	6	Liver cirrhosis; Liver disease
ATXN2	2	6	Biliary cholangitis; Biliary cirrhosis
BCL2	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
C1ORF53	2	6	Biliary cholangitis; Biliary cirrhosis
CA1	2	6	Biliary cholangitis; Biliary cirrhosis
CA2	2	6	Biliary cholangitis; Biliary cirrhosis
CACNA1S	2	6	Biliary cholangitis; Biliary cirrhosis
CACNA2D1	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
CAPSL	2	6	Biliary cholangitis; Biliary cirrhosis
CAT	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
CCDC88B	2	6	Biliary cholangitis; Biliary cirrhosis
CCL2	2	6	Liver cirrhosis; Liver disease
CCL20	2	6	Biliary cholangitis; Biliary cirrhosis
CCR2	2	6	Liver disease; Nonalcoholic fatty liver disease
CCR6	2	6	Biliary cholangitis; Biliary cirrhosis
CD14	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
CD226	2	6	Biliary cholangitis; Biliary cirrhosis
CD58	2	6	Biliary cholangitis; Biliary cirrhosis
CDC37	2	6	Biliary cholangitis; Biliary cirrhosis
CDH2	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
CEP43	2	6	Biliary cholangitis; Biliary cirrhosis
CFAP263	2	6	Biliary cholangitis; Biliary cirrhosis
CHST2	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
CNTN5	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
COL13A1	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
COL3A1	2	6	Liver cirrhosis; Liver disease
COMMD1	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
CRACR2A	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
CTLA4	2	6	Biliary cholangitis; Biliary cirrhosis
DCLK1	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
DDX6	2	6	Biliary cholangitis; Biliary cirrhosis
DDX60L	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
DEAF1	2	6	Biliary cholangitis; Biliary cirrhosis
DGKQ	2	6	Biliary cholangitis; Biliary cirrhosis
DLEU7	2	6	Biliary cholangitis; Biliary cirrhosis
DNMT3A	2	6	Biliary cholangitis; Biliary cirrhosis
DUS2	2	6	Biliary cholangitis; Biliary cirrhosis
EHBP1L1	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
EIF4E	2	6	Biliary cholangitis; Biliary cirrhosis
ELMO1	2	6	Biliary cholangitis; Biliary cirrhosis
ERLIN1	2	6	Liver disease; Nonalcoholic fatty liver disease
ETS1	2	6	Biliary cholangitis; Biliary cirrhosis
F2	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
FARP1	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
FBXL20	2	6	Biliary cholangitis; Biliary cirrhosis
FCRL3	2	6	Biliary cholangitis; Biliary cirrhosis
FCRL4	2	6	Biliary cholangitis; Biliary cirrhosis
FDFT1	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
FOCAD	2	6	Liver cirrhosis; Liver disease
GC	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
GCKR	2	6	Liver disease; Nonalcoholic fatty liver disease
GGT1	2	6	Liver disease; Nonalcoholic fatty liver disease
GLRA3	2	6	Biliary cholangitis; Biliary cirrhosis
GPAM	2	6	Liver disease; Nonalcoholic fatty liver disease
GPT	2	6	Liver disease; Nonalcoholic fatty liver disease
GSTM1	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
GSTP1	2	6	Liver disease; Nonalcoholic fatty liver disease
HEMGN	2	6	Biliary cholangitis; Biliary cirrhosis
HERPUD2	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
HKDC1	2	6	Liver cirrhosis; Liver disease
HLA-DRA	2	6	Biliary cholangitis; Biliary cirrhosis
HLA-DRB1	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
HPGD	2	6	Biliary cholangitis; Biliary cirrhosis
HS3ST1	2	6	Liver disease; Nonalcoholic fatty liver disease
HSD17B13	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
IKZF3	2	6	Biliary cholangitis; Biliary cirrhosis
IL12RB2	2	6	Biliary cholangitis; Biliary cirrhosis
IL16	2	6	Biliary cholangitis; Biliary cirrhosis
IL1RL2	2	6	Biliary cholangitis; Biliary cirrhosis
IL20RA	2	6	Biliary cholangitis; Biliary cirrhosis
IL21R	2	6	Biliary cholangitis; Biliary cirrhosis
IL22RA2	2	6	Biliary cholangitis; Biliary cirrhosis
IL4R	2	6	Biliary cholangitis; Biliary cirrhosis
IL6	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
INS	2	6	Liver disease; Nonalcoholic fatty liver disease
IRF5	2	6	Biliary cholangitis; Biliary cirrhosis
IRF8	2	6	Biliary cholangitis; Biliary cirrhosis
ITGB8	2	6	Biliary cholangitis; Biliary cirrhosis
JCAD	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
KIF21B	2	6	Biliary cholangitis; Biliary cirrhosis
LBR	2	6	Biliary cholangitis; Biliary cirrhosis
LCP1	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
LDLR	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
LEP	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
MACIR	2	6	Biliary cholangitis; Biliary cirrhosis
MACROD2	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
MANBA	2	6	Biliary cholangitis; Biliary cirrhosis
MAST3	2	6	Biliary cholangitis; Biliary cirrhosis
MBL2	2	6	Liver cirrhosis; Liver disease
MBOAT7	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
MLXIPL	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
MRTFA	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
MTTP	2	6	Liver disease; Nonalcoholic fatty liver disease
NAB1	2	6	Biliary cholangitis; Biliary cirrhosis
NDFIP1	2	6	Biliary cholangitis; Biliary cirrhosis
NFIC	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
NPC1	2	6	Liver cirrhosis; Liver disease
NQO1	2	6	Liver disease; Nonalcoholic fatty liver disease
NR1H4	2	6	Liver disease; Nonalcoholic fatty liver disease
NUP62	2	6	Biliary cholangitis; Biliary cirrhosis
PCSK5	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
PDGFB	2	6	Biliary cholangitis; Biliary cirrhosis
PEMT	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
PLCL2	2	6	Biliary cholangitis; Biliary cirrhosis
PLPPR4	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
POGLUT1	2	6	Biliary cholangitis; Biliary cirrhosis
POU2AF1	2	6	Biliary cholangitis; Biliary cirrhosis
PPARD	2	6	Liver disease; Nonalcoholic fatty liver disease
PRKCB	2	6	Biliary cholangitis; Biliary cirrhosis
PRORP	2	6	Biliary cholangitis; Biliary cirrhosis
PSMG4	2	6	Biliary cholangitis; Biliary cirrhosis
PTEN	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
RAD51B	2	6	Biliary cholangitis; Biliary cirrhosis
RARB	2	6	Biliary cholangitis; Biliary cirrhosis
RIN3	2	6	Biliary cholangitis; Biliary cirrhosis
RPL3	2	6	Biliary cholangitis; Biliary cirrhosis
RPS6KA4	2	6	Biliary cholangitis; Biliary cirrhosis
SEL1L3	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
SERPINE1	2	6	Liver cirrhosis; Liver disease
SH2B3	2	6	Biliary cholangitis; Biliary cirrhosis
SLC17A2	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
SLC22A23	2	6	Biliary cholangitis; Biliary cirrhosis
SLC38A8	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
SLC46A3	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
SLC9A9	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
SOD2	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
SPEF2	2	6	Biliary cholangitis; Biliary cirrhosis
SPP1	2	6	Liver cirrhosis; Liver disease
ST8SIA4	2	6	Biliary cholangitis; Biliary cirrhosis
SUGP1	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
SVIL	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
SYNGR1	2	6	Biliary cholangitis; Biliary cirrhosis
TBX20	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
TECTB	2	6	Liver disease; Nonalcoholic fatty liver disease
TET2	2	6	Biliary cholangitis; Biliary cirrhosis
TEX36	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
TG	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
TIMMDC1	2	6	Biliary cholangitis; Biliary cirrhosis
TJP2	2	6	Biliary cholangitis; Nonalcoholic fatty liver disease
TLCD4-RWDD3	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
TMEM163	2	6	Biliary cholangitis; Biliary cirrhosis
TMEM39A	2	6	Biliary cholangitis; Biliary cirrhosis
TNFRSF1B	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
TNFSF15	2	6	Biliary cholangitis; Biliary cirrhosis
TNPO3	2	6	Biliary cholangitis; Biliary cirrhosis
TRAPPC9	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
TRMT10A	2	6	Liver disease; Nonalcoholic fatty liver disease
UGT1A10	2	6	Liver disease; Nonalcoholic fatty liver disease
UGT1A3	2	6	Liver disease; Nonalcoholic fatty liver disease
UGT1A4	2	6	Liver disease; Nonalcoholic fatty liver disease
UGT1A5	2	6	Liver disease; Nonalcoholic fatty liver disease
UGT1A6	2	6	Liver disease; Nonalcoholic fatty liver disease
UGT1A7	2	6	Liver disease; Nonalcoholic fatty liver disease
UGT1A8	2	6	Liver disease; Nonalcoholic fatty liver disease
UGT1A9	2	6	Liver disease; Nonalcoholic fatty liver disease
UTP4	2	6	Biliary cholangitis; Biliary cirrhosis
VEGFA	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
VPS37D	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease
WDFY4	2	6	Biliary cholangitis; Biliary cirrhosis
ZC3HAV1	2	6	Biliary cholangitis; Biliary cirrhosis
ZP4	2	6	Liver cirrhosis; Nonalcoholic fatty liver disease