# GeDiPNet Cluster 288 -- Enriched Pathways -- generated 2026-10-07 18:51:43
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Interleukin-4 and Interleukin-13 signaling	Reactome	38	HIF1A, IL12A, IL12B, NOS2, TGFB1, TYK2, IL4R, CCL2, COL1A2, FGF2, FOXO3, HGF	108	696	6.07	1.678e-20	1.383e-17
Interleukin-10 signaling	Reactome	26	CCL5, CD80, CXCL10, IL12A, IL12B, TNFRSF1A, TYK2, CCL20, CCL2, ICAM1, IL10, IL6	47	696	9.55	1.738e-20	1.422e-17
AGE-RAGE signaling pathway in diabetic complications	KEGG	36	MAPK14, NFKB1, NOS3, RELA, TGFB1, PRKCB, AGT, CCL2, COL1A1, COL1A2, COL3A1, F3	101	696	6.15	1.054e-19	7.917e-17
Pathways in cancer	KEGG	87	HIF1A, IL12A, IL12B, IL7R, KEAP1, NFE2L2, NFKB1, NOS2, RELA, STAT4, TGFB1, ETS1	533	696	2.82	3.528e-19	2.547e-16
Inflammatory bowel disease	KEGG	27	HLA-DQA1, IL12A, IL12B, NFKB1, RELA, STAT4, TGFB1, HLA-DPB1, HLA-DQB1, HLA-DRA, IL12RB2, IL21R	66	696	7.06	7.008e-17	3.249e-14
Allograft rejection	KEGG	20	CD80, HLA-DQA1, IL12A, IL12B, HLA-DPB1, HLA-DQB1, HLA-DRA, HLA-B, HLA-DPA1, HLA-DRB1, IFNG, IL10	39	696	8.85	3.402e-15	1.185e-12
Type I diabetes mellitus	KEGG	21	CD80, HLA-DQA1, IL12A, IL12B, HLA-DPB1, HLA-DQB1, HLA-DRA, HLA-B, HLA-DPA1, HLA-DRB1, IFNG, TNF	44	696	8.24	4.486e-15	1.534e-12
Leishmaniasis	KEGG	27	HLA-DQA1, IL12A, IL12B, MAPK14, NFKB1, NOS2, RELA, TGFB1, HLA-DPB1, HLA-DQB1, HLA-DRA, PRKCB	78	696	5.97	9.868e-15	3.088e-12
Influenza A	KEGG	40	CCL5, CXCL10, HLA-DQA1, IL12A, IL12B, NFKB1, RELA, TNFRSF1A, TYK2, HLA-DPB1, HLA-DQB1, HLA-DRA	173	696	3.99	2.263e-14	6.527e-12
Cytokine-cytokine receptor interaction	KEGG	54	CCL5, CXCL10, CXCL9, CXCR5, IL12A, IL12B, IL7R, TGFB1, TNFRSF1A, CCL20, CCR6, IL12RB2	298	696	3.13	3.798e-14	1.038e-11
Th17 cell differentiation	KEGG	31	CD3D, HIF1A, HLA-DQA1, MAPK14, NFKB1, RELA, TGFB1, TYK2, HLA-DPB1, HLA-DQB1, HLA-DRA, IL21R	109	696	4.91	4.941e-14	1.321e-11
Fluid shear stress and atherosclerosis	KEGG	35	CDH5, KEAP1, MAPK14, NFE2L2, NFKB1, NOS3, RELA, TNFRSF1A, PDGFB, CCL2, CTNNB1, CYBA	141	696	4.28	1.029e-13	2.625e-11
Toxoplasmosis	KEGG	31	HLA-DQA1, IL12A, IL12B, MAPK14, NFKB1, NOS2, RELA, TGFB1, TNFRSF1A, TYK2, HLA-DPB1, HLA-DQB1	112	696	4.78	1.118e-13	2.826e-11
Graft-versus-host disease	KEGG	20	CD80, HLA-DQA1, HLA-DPB1, HLA-DQB1, HLA-DRA, HLA-B, HLA-DPA1, HLA-DRB1, IFNG, IL6, KIR3DS1, TNF	45	696	7.67	1.124e-13	2.834e-11
MAPK signaling pathway	KEGG	52	MAPK14, NFKB1, RELA, TGFB1, TNFRSF1A, CACNA1S, PDGFB, PRKCB, RPS6KA4, CACNA2D1, MAPKAPK5, ARRB1	299	696	3.00	6.219e-13	1.410e-10