# GeDiPNet Cluster 285 -- Enriched Pathways -- generated 2026-10-08 02:19:21
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Defective ABCC8 can cause hypoglycemias and hyperglycemias	Reactome	1	ABCC8	2	7	857.86	1.165e-3	1.560e-2
ATP sensitive Potassium channels	Reactome	1	ABCC8	4	7	428.93	2.330e-3	2.607e-2
Regulation of MECP2 expression and activity	Reactome	1	LBR	6	7	285.95	3.493e-3	3.476e-2
Transcriptional misregulation in cancer	KEGG	2	NSD2, CEBPE	198	7	17.33	5.378e-3	4.689e-2
Regulation of insulin secretion	Reactome	1	ABCC8	16	7	107.23	9.291e-3	6.693e-2
Initiation of Nuclear Envelope (NE) Reformation	Reactome	1	LBR	19	7	90.30	1.102e-2	7.440e-2
Steroid biosynthesis	KEGG	1	LBR	20	7	85.79	1.160e-2	7.656e-2
Cholesterol biosynthesis	Reactome	1	LBR	21	7	81.70	1.218e-2	7.914e-2
ABC transporters	KEGG	1	ABCC8	45	7	38.13	2.594e-2	1.230e-1
Type II diabetes mellitus	KEGG	1	ABCC8	47	7	36.50	2.708e-2	1.257e-1
HDMs demethylate histones	Reactome	1	ARID5B	50	7	34.31	2.879e-2	1.297e-1
Lysine degradation	KEGG	1	NSD2	63	7	27.23	3.616e-2	1.467e-1
Acute myeloid leukemia	KEGG	1	CEBPE	68	7	25.23	3.898e-2	1.526e-1
Nonhomologous End-Joining (NHEJ)	Reactome	1	NSD2	69	7	24.87	3.954e-2	1.537e-1
PKMTs methylate histone lysines	Reactome	1	NSD2	71	7	24.16	4.067e-2	1.559e-1