# GeDiPNet Cluster 283 -- Enriched Pathways -- generated 2026-10-07 10:49:51
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
MET activates PTK2 signaling	Reactome	3	COL24A1, COL5A1, LAMB1	30	33	36.39	7.295e-5	1.730e-3
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	Reactome	2	RXRA, AKR1C4	15	33	48.53	7.518e-4	1.095e-2
IL-6-type cytokine receptor ligand interactions	Reactome	2	TYK2, LIFR	17	33	42.82	9.704e-4	1.325e-2
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Reactome	2	RXRA, AKR1C4	24	33	30.33	1.946e-3	2.234e-2
Dopamine clearance from the synaptic cleft	Reactome	1	SLC6A3	1	33	363.94	2.748e-3	2.889e-2
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	Reactome	1	SLC6A3	1	33	363.94	2.748e-3	2.889e-2
Th17 cell differentiation	KEGG	3	RXRA, HLA-DRB4, TYK2	109	33	10.02	3.255e-3	3.261e-2
Toxoplasmosis	KEGG	3	LAMB1, HLA-DRB4, TYK2	112	33	9.75	3.514e-3	3.435e-2
Allograft rejection	KEGG	2	HLA-A, HLA-DRB4	39	33	18.66	5.091e-3	4.425e-2
Formation of the cornified envelope	Reactome	3	KRT3, KRT4, KRT13	130	33	8.40	5.334e-3	4.565e-2
N-glycan trimming and elongation in the cis-Golgi	Reactome	1	MANEA	2	33	181.97	5.488e-3	4.649e-2
Type I diabetes mellitus	KEGG	2	HLA-A, HLA-DRB4	44	33	16.54	6.444e-3	5.175e-2
Collagen chain trimerization	Reactome	2	COL24A1, COL5A1	44	33	16.54	6.444e-3	5.175e-2
Graft-versus-host disease	KEGG	2	HLA-A, HLA-DRB4	45	33	16.18	6.733e-3	5.320e-2
Keratinization	Reactome	3	KRT3, KRT4, KRT13	152	33	7.18	8.212e-3	6.072e-2