# GeDiPNet Cluster 280 -- Enriched Pathways -- generated 2026-10-09 08:02:25
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
DCC mediated attractive signaling	Reactome	2	RAC1, TRIO	11	36	60.66	4.724e-4	7.553e-3
Signal transduction by L1	Reactome	2	CSNK2A1, RAC1	21	36	31.77	1.770e-3	2.087e-2
Polycomb repressive complex	KEGG	3	AUTS2, ASXL2, ASXL3	83	36	12.06	1.928e-3	2.219e-2
Regulation of TP53 Activity through Acetylation	Reactome	2	KAT6A, CHD4	23	36	29.01	2.124e-3	2.381e-2
Processing of Capped Intron-Containing Pre-mRNA	Reactome	2	HNRNPR, HNRNPH1	37	36	18.03	5.447e-3	4.642e-2
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Reactome	2	AUTS2, CSNK2A1	38	36	17.56	5.739e-3	4.798e-2
HDMs demethylate histones	Reactome	2	KDM3B, KDM6B	50	36	13.34	9.778e-3	6.837e-2
NRAGE signals death through JNK	Reactome	2	RAC1, TRIO	55	36	12.13	1.174e-2	7.658e-2
NTRK2 activates RAC1	Reactome	1	RAC1	5	36	66.72	1.490e-2	8.817e-2
Lysine degradation	KEGG	2	KMT2C, NSD2	63	36	10.59	1.521e-2	8.945e-2
Transcriptional regulation of white adipocyte differentiation	Reactome	2	MED13L, MED23	67	36	9.96	1.710e-2	9.624e-2
mRNA Splicing - Major Pathway	Reactome	3	HNRNPR, PUF60, HNRNPH1	183	36	5.47	1.719e-2	9.653e-2
PKMTs methylate histone lysines	Reactome	2	KMT2C, NSD2	71	36	9.40	1.907e-2	1.024e-1
Condensation of Prometaphase Chromosomes	Reactome	1	CSNK2A1	8	36	41.70	2.374e-2	1.157e-1
Sema4D mediated inhibition of cell attachment and migration	Reactome	1	RAC1	8	36	41.70	2.374e-2	1.157e-1