# GeDiPNet Cluster 27 -- Top Shared Genes -- generated 2026-10-09 07:37:25
# Curated genes (disease_gdp) linked to 2 or more of this cluster's member diseases, most widely shared first. Data as of: 2026-10-09 03:15:01.
Gene	Member Diseases Linked	Cluster Size	Linked Diseases
ND4	9	18	Cleft palate and bilateral cleft lip; Congenital cardiomyopathy; Developmental delay; Leber hereditary optic neuropathy; Melas syndrome; Neuropathy, ataxia, and retinitis pigmentosa; Optic neuropathy; Postaxial polydactyly; Rod-cone dystrophy
ND5	9	18	Cleft palate and bilateral cleft lip; Congenital cardiomyopathy; Developmental delay; Leber hereditary optic neuropathy; Melas syndrome; Myoclonic epilepsy with ragged red fibers; Neuropathy, ataxia, and retinitis pigmentosa; Postaxial polydactyly; Rod-cone dystrophy
ATP8	8	18	Cleft palate and bilateral cleft lip; Leber hereditary optic neuropathy; Melas syndrome; Neuropathy, ataxia, and retinitis pigmentosa; Optic neuropathy; Periodic paralysis with later-onset distal motor neuropathy; Postaxial polydactyly; Rod-cone dystrophy
COX3	8	18	Cleft palate and bilateral cleft lip; Developmental delay; Leber hereditary optic neuropathy; Melas syndrome; Mitochondrial encephalopathy; Neuropathy, ataxia, and retinitis pigmentosa; Postaxial polydactyly; Rod-cone dystrophy
ATP6	7	18	Cleft palate and bilateral cleft lip; Leber hereditary optic neuropathy; Melas syndrome; Neuropathy, ataxia, and retinitis pigmentosa; Optic neuropathy; Postaxial polydactyly; Rod-cone dystrophy
ND1	7	18	Cleft palate and bilateral cleft lip; Leber hereditary optic neuropathy; Melas syndrome; Neuropathy, ataxia, and retinitis pigmentosa; Optic neuropathy; Postaxial polydactyly; Rod-cone dystrophy
ND2	7	18	Cleft palate and bilateral cleft lip; Developmental delay; Leber hereditary optic neuropathy; Melas syndrome; Neuropathy, ataxia, and retinitis pigmentosa; Postaxial polydactyly; Rod-cone dystrophy
COX1	6	18	Cleft palate and bilateral cleft lip; Leber hereditary optic neuropathy; Melas syndrome; Neuropathy, ataxia, and retinitis pigmentosa; Postaxial polydactyly; Rod-cone dystrophy
COX2	6	18	Cleft palate and bilateral cleft lip; Leber hereditary optic neuropathy; Melas syndrome; Neuropathy, ataxia, and retinitis pigmentosa; Postaxial polydactyly; Rod-cone dystrophy
ND3	6	18	Cleft palate and bilateral cleft lip; Leber hereditary optic neuropathy; Melas syndrome; Neuropathy, ataxia, and retinitis pigmentosa; Postaxial polydactyly; Rod-cone dystrophy
IL1A	5	18	Leber hereditary optic neuropathy; Melas syndrome; Mitochondrial myopathy; Myoclonic epilepsy with ragged red fibers; Progressive external ophthalmoplegia
IL1B	5	18	Leber hereditary optic neuropathy; Melas syndrome; Mitochondrial myopathy; Myoclonic epilepsy with ragged red fibers; Progressive external ophthalmoplegia
ND4L	5	18	Cleft palate and bilateral cleft lip; Leber hereditary optic neuropathy; Neuropathy, ataxia, and retinitis pigmentosa; Postaxial polydactyly; Rod-cone dystrophy
CYTB	4	18	Developmental delay; Leber hereditary optic neuropathy; Melas syndrome; Mitochondrial myopathy
RRM2B	3	18	Mitochondrial myopathy; Progressive external ophthalmoplegia; Rod-cone dystrophy
SOD2	3	18	Leber hereditary optic neuropathy; Melas syndrome; Progressive external ophthalmoplegia
BBIP1	2	18	Postaxial polydactyly; Rod-cone dystrophy
CSF3	2	18	Optic neuropathy; Stomatitis
FBXW7	2	18	Developmental delay; Developmental delay with hypotonia and impaired language
FOXRED1	2	18	Developmental delay; Mitochondrial encephalopathy
IFNA2	2	18	Optic neuropathy; Stomatitis
LMBRD2	2	18	Developmental delay; Developmental delay with variable neurological abnormalities
LRAT	2	18	Leber hereditary optic neuropathy; Rod-cone dystrophy
ND6	2	18	Leber hereditary optic neuropathy; Melas syndrome
PIGL	2	18	Cleft palate and bilateral cleft lip; Postaxial polydactyly
POLG	2	18	Melas syndrome; Progressive external ophthalmoplegia
RPE65	2	18	Leber hereditary optic neuropathy; Rod-cone dystrophy
SETD1B	2	18	Developmental delay; Intellectual developmental disorder seizures language
SLC25A4	2	18	Mitochondrial myopathy; Progressive external ophthalmoplegia
SOD1	2	18	Melas syndrome; Progressive external ophthalmoplegia
TK2	2	18	Mitochondrial myopathy; Progressive external ophthalmoplegia