# GeDiPNet Cluster 27 -- Enriched Pathways -- generated 2026-10-09 01:21:19
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Prion disease	KEGG	23	SLC25A4, IL1A, IL1B, SOD1, ATP6, ATP8, COX1, COX2, COX3, ND1, ND2, ND3	275	128	7.85	1.210e-14	3.350e-12
Chemical carcinogenesis - reactive oxygen species	KEGG	20	SLC25A4, SOD1, SOD2, ATP6, ATP8, COX1, COX2, COX3, ND1, ND2, ND3, ND4	227	128	8.27	2.889e-13	6.214e-11
Diabetic cardiomyopathy	KEGG	18	SLC25A4, ATP6, ATP8, COX1, COX2, COX3, ND1, ND2, ND3, ND4, ND4L, ND5	205	128	8.24	5.225e-12	9.263e-10
Huntington disease	KEGG	21	SLC25A4, SOD1, SOD2, ATP6, ATP8, COX1, COX2, COX3, ND1, ND2, ND3, ND4	308	128	6.40	1.017e-11	1.712e-9
Oxidative phosphorylation	KEGG	15	ATP6, ATP8, COX1, COX2, COX3, ND1, ND2, ND3, ND4, ND4L, ND5, CYTB	137	128	10.27	1.466e-11	2.371e-9
Parkinson disease	KEGG	19	SLC25A4, SOD1, ATP6, ATP8, COX1, COX2, COX3, ND1, ND2, ND3, ND4, ND4L	268	128	6.65	5.531e-11	7.849e-9
Respiratory electron transport	Reactome	12	COX1, COX2, COX3, ND1, ND2, ND3, ND4, ND5, CYTB, NDUFS2, ND6, NDUFS1	83	128	13.57	6.500e-11	9.130e-9
Alzheimer disease	KEGG	22	SLC25A4, IL1A, IL1B, ATP6, ATP8, COX1, COX2, COX3, ND1, ND2, ND3, ND4	388	128	5.32	1.147e-10	1.543e-8
Amyotrophic lateral sclerosis	KEGG	21	SOD1, ATP6, ATP8, COX1, COX2, COX3, ND1, ND2, ND3, ND4, ND4L, ND5	368	128	5.35	2.842e-10	3.447e-8
Pathways of neurodegeneration - multiple diseases	KEGG	23	SLC25A4, IL1A, IL1B, SOD1, ATP6, ATP8, COX1, COX2, COX3, ND1, ND2, ND3	480	128	4.50	1.142e-9	1.188e-7
Thermogenesis	KEGG	16	ATP6, ATP8, COX1, COX2, COX3, ND1, ND2, ND3, ND4, ND4L, ND5, CYTB	234	128	6.42	3.479e-9	3.258e-7
Complex I biogenesis	Reactome	9	ND1, ND2, ND3, ND4, ND5, NDUFS2, ND6, NDUFAF5, NDUFS1	55	128	15.35	5.619e-9	5.037e-7
Retrograde endocannabinoid signaling	KEGG	10	ND1, ND2, ND3, ND4, ND4L, ND5, GNAO1, NDUFS2, ND6, NDUFS1	149	128	6.30	4.148e-6	1.584e-4
Non-alcoholic fatty liver disease	KEGG	10	IL1A, IL1B, COX1, COX2, COX3, CYTB, NDUFS2, NDUFS1, IL6, TNF	157	128	5.98	6.619e-6	2.300e-4
The canonical retinoid cycle in rods (twilight vision)	Reactome	4	LRAT, RDH12, RPE65, RHO	20	128	18.77	5.225e-5	1.284e-3