# GeDiPNet Cluster 265 -- Enriched Pathways -- generated 2026-10-07 00:42:35
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Collecting duct acid secretion	KEGG	3	TCIRG1, CA2, CLCNKB	28	20	64.34	1.260e-5	4.070e-4
Stimuli-sensing channels	Reactome	3	CLCN7, OSTM1, CLCNKB	79	20	22.80	2.881e-4	5.196e-3
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Reactome	2	TNFSF11, TNFRSF11A	18	20	66.72	3.967e-4	6.664e-3
Rheumatoid arthritis	KEGG	3	TCIRG1, TNFSF11, TNFRSF11A	95	20	18.96	4.958e-4	7.918e-3
Disassembly of the destruction complex and recruitment of AXIN to the membrane	Reactome	2	LRP5, CTNNB1	30	20	40.03	1.114e-3	1.470e-2
Breast cancer	KEGG	3	LRP5, TNFSF11, CTNNB1	148	20	12.17	1.792e-3	2.107e-2
Intracellular metabolism of fatty acids regulates insulin secretion	Reactome	1	CD36	3	20	200.17	4.988e-3	4.365e-2
TNFR2 non-canonical NF-kB pathway	Reactome	2	TNFSF11, TNFRSF11A	69	20	17.41	5.781e-3	4.828e-2
Prolactin signaling pathway	KEGG	2	TNFSF11, TNFRSF11A	71	20	16.92	6.112e-3	4.998e-2
Toll Like Receptor TLR6:TLR2 Cascade	Reactome	1	CD36	4	20	150.13	6.645e-3	5.278e-2
Gastric acid secretion	KEGG	2	CA2, SLC4A2	76	20	15.80	6.975e-3	5.451e-2
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	Reactome	1	CTNNB1	5	20	120.10	8.300e-3	6.104e-2
Scavenging by Class B Receptors	Reactome	1	CD36	5	20	120.10	8.300e-3	6.104e-2
Bile secretion	KEGG	2	CA2, SLC4A2	90	20	13.34	9.666e-3	6.727e-2
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	Reactome	1	LRP5	6	20	100.08	9.952e-3	6.820e-2