# GeDiPNet Cluster 262 -- Enriched Pathways -- generated 2026-10-07 02:19:58
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
MET activates PTK2 signaling	Reactome	8	COL24A1, COL5A1, LAMA2, LAMB1, COL11A1, COL2A1, HGF, LAMA5	30	284	11.28	3.300e-7	1.864e-5
Collagen biosynthesis and modifying enzymes	Reactome	10	COL24A1, COL5A1, COL11A1, COL2A1, COL4A4, COL9A1, P3H2, P4HA2, COL17A1, COL18A1	67	284	6.31	3.521e-6	1.420e-4
Collagen chain trimerization	Reactome	8	COL24A1, COL5A1, COL11A1, COL2A1, COL4A4, COL9A1, COL17A1, COL18A1	44	284	7.69	7.495e-6	2.633e-4
Assembly of collagen fibrils and other multimeric structures	Reactome	8	COL24A1, COL5A1, COL11A1, COL2A1, COL4A4, COL9A1, COL17A1, COL18A1	51	284	6.63	2.333e-5	6.776e-4
Protein digestion and absorption	KEGG	10	COL24A1, COL5A1, FXYD2, COL11A1, COL2A1, COL4A4, COL9A1, COL17A1, COL18A1, SLC6A19	103	284	4.11	1.585e-4	3.251e-3
Carnitine metabolism	Reactome	4	RXRA, CPT1B, PRKAA2, SLC22A5	14	284	12.08	2.541e-4	4.704e-3
Laminin interactions	Reactome	5	LAMA2, LAMB1, COL4A4, COL18A1, LAMA5	28	284	7.55	4.488e-4	7.319e-3
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)	Reactome	2	MC2R, POMC	2	284	42.29	5.573e-4	8.667e-3
Integrin cell surface interactions	Reactome	8	COL5A1, COL2A1, COL4A4, COL9A1, FBN1, TNC, COL18A1, KDR	81	284	4.18	6.392e-4	9.660e-3
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Reactome	10	BMP4, IL6, LAMB1, APOE, FBN1, IGF1, MMP2, TNC, FUCA2, PCSK9	125	284	3.38	7.561e-4	1.100e-2
PI3K-Akt signaling pathway	KEGG	19	GNB3, IL6, JAK2, LAMA2, LAMB1, NTF4, RXRA, GNGT2, COL2A1, COL4A4, COL9A1, HGF	361	284	2.23	9.604e-4	1.316e-2
The canonical retinoid cycle in rods (twilight vision)	Reactome	4	RDH5, LRAT, RLBP1, RPE65	20	284	8.46	1.100e-3	1.456e-2
ECM-receptor interaction	KEGG	8	LAMA2, LAMB1, AGRN, COL2A1, COL4A4, COL9A1, TNC, LAMA5	89	284	3.80	1.193e-3	1.547e-2
ECM proteoglycans	Reactome	6	COL5A1, AGRN, COL2A1, COL9A1, TNC, BCAN	51	284	4.98	1.222e-3	1.577e-2
NCAM1 interactions	Reactome	4	COL5A1, COL2A1, COL4A4, COL9A1	21	284	8.05	1.333e-3	1.682e-2