# GeDiPNet Cluster 261 -- Enriched Pathways -- generated 2026-10-09 09:39:29
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Retrograde endocannabinoid signaling	KEGG	5	PTGS2, GRIA1, PRKCA, GABRA4, GABRB1	149	53	7.60	4.883e-4	7.734e-3
Nicotine addiction	KEGG	3	GRIA1, GABRA4, GABRB1	41	53	16.58	7.684e-4	1.098e-2
Serotonergic synapse	KEGG	4	PLA2G4A, PTGS2, PRKCA, GABRB1	115	53	7.88	1.628e-3	1.958e-2
GABA receptor activation	Reactome	2	GABRA4, GABRB1	16	53	28.33	2.204e-3	2.447e-2
Syndecan interactions	Reactome	2	TGFB1, PRKCA	16	53	28.33	2.204e-3	2.447e-2
VEGF signaling pathway	KEGG	3	PLA2G4A, PTGS2, PRKCA	60	53	11.33	2.325e-3	2.545e-2
Long-term depression	KEGG	3	PLA2G4A, GRIA1, PRKCA	60	53	11.33	2.325e-3	2.545e-2
Trafficking of GluR2-containing AMPA receptors	Reactome	2	GRIA1, PRKCA	17	53	26.66	2.491e-3	2.679e-2
Fc epsilon RI signaling pathway	KEGG	3	PLA2G4A, LAT, PRKCA	69	53	9.85	3.462e-3	3.393e-2
Biosynthesis of EPA-derived SPMs	Reactome	1	PTGS2	1	53	226.60	4.413e-3	4.026e-2
Biosynthesis of DPAn-3 SPMs	Reactome	1	PTGS2	1	53	226.60	4.413e-3	4.026e-2
Leishmaniasis	KEGG	3	NOS2, PTGS2, TGFB1	78	53	8.72	4.889e-3	4.312e-2
Efferocytosis	KEGG	4	PTGS2, TGFB1, CALR, STAB2	157	53	5.77	5.006e-3	4.373e-2
GABAergic synapse	KEGG	3	PRKCA, GABRA4, GABRB1	89	53	7.64	7.055e-3	5.502e-2
Morphine addiction	KEGG	3	PRKCA, GABRA4, GABRB1	91	53	7.47	7.500e-3	5.724e-2