# GeDiPNet Cluster 259 -- Enriched Pathways -- generated 2026-10-07 06:32:17
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Parathyroid hormone synthesis, secretion and action	KEGG	9	PTH, PTHLH, TNFSF11, CASR, CYP24A1, SLC34A1, TRPV5, CYP27B1, KL	115	29	32.41	4.203e-12	8.088e-10
ADORA2B mediated anti-inflammatory cytokines production	Reactome	6	PTH, PTHLH, CALCA, CALCR, IL6, POMC	128	29	19.41	5.062e-7	2.711e-5
Rheumatoid arthritis	KEGG	5	CXCL2, PTH, TNFSF11, IL6, TNF	95	29	21.80	2.846e-6	1.189e-4
Hormone signaling	KEGG	6	GHRL, PTH, PTHLH, CALCA, CALCR, POMC	219	29	11.35	1.148e-5	3.760e-4
G alpha (s) signalling events	Reactome	5	PTH, PTHLH, CALCA, CALCR, POMC	140	29	14.79	1.900e-5	5.751e-4
Endogenous sterols	Reactome	3	AHR, CYP19A1, POMC	25	29	49.70	2.809e-5	7.889e-4
Cytokine-cytokine receptor interaction	KEGG	6	BMP7, CXCL2, TNFRSF11B, TNFSF11, IL6, TNF	298	29	8.34	6.512e-5	1.580e-3
NOD-like receptor signaling pathway	KEGG	5	CXCL2, CASR, IL6, TNF, ANTXR2	187	29	11.07	7.604e-5	1.793e-3
Vitamins	Reactome	2	CYP24A1, CYP27B1	6	29	138.05	8.394e-5	1.946e-3
Interleukin-10 signaling	Reactome	3	CXCL2, IL6, TNF	47	29	26.43	1.911e-4	3.772e-3
Calcitonin-like ligand receptors	Reactome	2	CALCA, CALCR	10	29	82.83	2.503e-4	4.654e-3
Endocrine and other factor-regulated calcium reabsorption	KEGG	3	PTH, TRPV5, KL	53	29	23.44	2.734e-4	4.987e-3
Vitamin D (calciferol) metabolism	Reactome	2	CYP24A1, CYP27B1	11	29	75.30	3.055e-4	5.443e-3
Legionellosis	KEGG	3	CXCL2, IL6, TNF	56	29	22.19	3.220e-4	5.670e-3
Osteoclast differentiation	KEGG	4	TNFRSF11B, TNFSF11, CALCR, TNF	142	29	11.67	3.536e-4	6.097e-3