# GeDiPNet Cluster 258 -- Enriched Pathways -- generated 2026-10-07 11:25:32
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Striated Muscle Contraction	Reactome	8	ACTC1, MYH3, TNNI1, TPM2, MYBPC1, MYH8, TNNI2, TNNT3	36	24	111.20	2.010e-15	7.327e-13
Motor proteins	KEGG	8	ACTC1, MYH3, MYO9A, TNNI1, TPM2, MYH8, TNNI2, TNNT3	194	24	20.64	2.365e-9	2.392e-7
Cytoskeleton in muscle cells	KEGG	8	ACTC1, MYH3, TNNI1, TPM2, MYBPC1, MYH8, TNNI2, TNNT3	232	24	17.26	9.683e-9	8.461e-7
MET activates STAT3	Reactome	1	MET	3	24	166.81	5.984e-3	4.925e-2
MECP2 regulates neuronal receptors and channels	Reactome	1	MET	4	24	125.10	7.970e-3	5.956e-2
MET activates PTPN11	Reactome	1	MET	5	24	100.08	9.953e-3	6.820e-2
MET interacts with TNS proteins	Reactome	1	MET	5	24	100.08	9.953e-3	6.820e-2
Stimuli-sensing channels	Reactome	2	NALCN, RYR1	79	24	12.67	1.074e-2	7.176e-2
MET Receptor Activation	Reactome	1	MET	6	24	83.40	1.193e-2	7.605e-2
MET activates PI3K/AKT signaling	Reactome	1	MET	6	24	83.40	1.193e-2	7.605e-2
Cardiac muscle contraction	KEGG	2	ACTC1, TPM2	87	24	11.50	1.291e-2	7.945e-2
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	Reactome	1	CHRNG	7	24	71.49	1.391e-2	8.315e-2
InlB-mediated entry of Listeria monocytogenes into host cell	Reactome	1	MET	7	24	71.49	1.391e-2	8.315e-2
Sema4D mediated inhibition of cell attachment and migration	Reactome	1	MET	8	24	62.55	1.588e-2	9.016e-2
Hypertrophic cardiomyopathy	KEGG	2	ACTC1, TPM2	99	24	10.11	1.650e-2	9.217e-2