# GeDiPNet Cluster 256 -- Enriched Pathways -- generated 2026-10-08 10:41:51
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Tie2 Signaling	Reactome	3	TEK, KRAS, PIK3CA	18	10	200.17	3.370e-7	1.897e-5
Downstream signal transduction	Reactome	3	RASA1, KRAS, PIK3CA	29	10	124.24	1.502e-6	6.935e-5
Axon guidance	KEGG	4	RASA1, EPHB4, KRAS, PIK3CA	183	10	26.25	1.020e-5	3.472e-4
GnRH secretion	KEGG	3	GNA11, KRAS, PIK3CA	65	10	55.43	1.767e-5	5.488e-4
Signaling by FGFR3 fusions in cancer	Reactome	2	KRAS, PIK3CA	10	10	240.20	2.798e-5	8.031e-4
Ras signaling pathway	KEGG	4	RASA1, TEK, KRAS, PIK3CA	237	10	20.27	2.828e-5	8.096e-4
Signaling by FGFR4 in disease	Reactome	2	KRAS, PIK3CA	11	10	218.36	3.418e-5	9.459e-4
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	Reactome	2	KRAS, PIK3CA	12	10	200.17	4.100e-5	1.104e-3
Signaling by PDGFRA extracellular domain mutants	Reactome	2	KRAS, PIK3CA	12	10	200.17	4.100e-5	1.104e-3
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	Reactome	2	RASA1, KRAS	14	10	171.57	5.648e-5	1.429e-3
VEGFR2 mediated cell proliferation	Reactome	2	RASA1, KRAS	14	10	171.57	5.648e-5	1.429e-3
Constitutive Signaling by EGFRvIII	Reactome	2	KRAS, PIK3CA	15	10	160.13	6.514e-5	1.602e-3
Signaling by ERBB2 ECD mutants	Reactome	2	KRAS, PIK3CA	16	10	150.13	7.442e-5	1.780e-3
Cholinergic synapse	KEGG	3	GNA11, KRAS, PIK3CA	115	10	31.33	9.773e-5	2.229e-3
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	Reactome	2	KRAS, PIK3CA	19	10	126.42	1.059e-4	2.376e-3