# GeDiPNet Cluster 255 -- Enriched Pathways -- generated 2026-10-07 22:21:55
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Arrhythmogenic right ventricular cardiomyopathy	KEGG	4	DSP, JUP, LMNA, RYR2	86	5	111.72	1.219e-8	1.008e-6
Cytoskeleton in muscle cells	KEGG	4	DSP, JUP, LMNA, TTN	232	5	41.41	6.684e-7	3.426e-5
Hypertrophic cardiomyopathy	KEGG	3	LMNA, TTN, RYR2	99	5	72.79	5.369e-6	2.055e-4
Dilated cardiomyopathy	KEGG	3	LMNA, TTN, RYR2	105	5	68.63	6.412e-6	2.364e-4
Formation of the cornified envelope	Reactome	2	DSP, JUP	130	5	36.95	1.138e-3	1.532e-2
Breakdown of the nuclear lamina	Reactome	1	LMNA	3	5	800.67	1.249e-3	1.645e-2
Keratinization	Reactome	2	DSP, JUP	152	5	31.61	1.552e-3	1.940e-2
Nuclear Envelope Breakdown	Reactome	1	LMNA	9	5	266.89	3.742e-3	3.650e-2
Apoptotic cleavage of cell adhesion  proteins	Reactome	1	DSP	11	5	218.36	4.572e-3	4.188e-2
Depolymerisation of the Nuclear Lamina	Reactome	1	LMNA	15	5	160.13	6.230e-3	5.168e-2
Initiation of Nuclear Envelope (NE) Reformation	Reactome	1	LMNA	19	5	126.42	7.886e-3	6.037e-2
VEGFR2 mediated vascular permeability	Reactome	1	JUP	29	5	82.83	1.202e-2	7.829e-2
Adherens junctions interactions	Reactome	1	JUP	32	5	75.06	1.325e-2	8.310e-2
Neutrophil degranulation	Reactome	2	DSP, JUP	480	5	10.01	1.471e-2	8.859e-2
Striated Muscle Contraction	Reactome	1	TTN	36	5	66.72	1.490e-2	8.912e-2