# GeDiPNet Cluster 252 -- Enriched Pathways -- generated 2026-10-08 00:50:29
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Prolactin receptor signaling	Reactome	2	CSH1, GH2	12	23	87.03	2.289e-4	4.391e-3
Growth hormone receptor signaling	Reactome	2	CSH1, GH2	14	23	74.60	3.148e-4	5.651e-3
Hormone signaling	KEGG	4	IGF2, PIK3CA, CSH1, GH2	219	23	9.54	7.254e-4	1.088e-2
Growth hormone synthesis, secretion and action	KEGG	3	PIK3CA, CSH1, GH2	122	23	12.84	1.561e-3	1.948e-2
Signaling by SCF-KIT	Reactome	2	PIK3CA, GRB10	37	23	28.23	2.243e-3	2.539e-2
RET signaling	Reactome	2	PIK3CA, GRB10	40	23	26.11	2.618e-3	2.846e-2
JAK-STAT signaling pathway	KEGG	3	PIK3CA, CSH1, GH2	168	23	9.32	3.876e-3	3.744e-2
PI3K-Akt signaling pathway	KEGG	4	IGF2, PIK3CA, CSH1, GH2	361	23	5.79	4.520e-3	4.159e-2
SUMOylation of DNA methylation proteins	Reactome	1	DNMT1	4	23	130.54	7.639e-3	5.898e-2
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	Reactome	1	IGF2	4	23	130.54	7.639e-3	5.898e-2
IRS activation	Reactome	1	GRB10	5	23	104.43	9.540e-3	6.798e-2
MET activates PI3K/AKT signaling	Reactome	1	PIK3CA	6	23	87.03	1.144e-2	7.595e-2
SHC-related events triggered by IGF1R	Reactome	1	IGF2	6	23	87.03	1.144e-2	7.595e-2
Insulin receptor signalling cascade	Reactome	1	GRB10	6	23	87.03	1.144e-2	7.595e-2
IRS-related events triggered by IGF1R	Reactome	1	IGF2	6	23	87.03	1.144e-2	7.595e-2