# GeDiPNet Cluster 250 -- Enriched Pathways -- generated 2026-10-07 22:11:36
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Cholesterol metabolism	KEGG	18	ABCG8, ANGPTL4, APOB, APOC1, APOE, CYP7A1, LDLR, LIPC, LPA, LPL, PCSK9, PLTP	51	166	25.54	2.498e-21	2.099e-18
Chylomicron remodeling	Reactome	6	APOA5, APOB, APOE, LPL, APOC2, APOC3	9	166	48.23	5.171e-10	5.958e-8
HDL remodeling	Reactome	5	APOE, PLTP, CETP, APOC2, APOC3	10	166	36.17	1.132e-7	7.285e-6
Chylomicron clearance	Reactome	4	APOB, APOE, LDLR, LIPC	5	166	57.88	1.742e-7	1.065e-5
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Reactome	7	ABCG8, APOC1, APOE, PLTP, CETP, ABCA1, APOC2	37	166	13.69	6.167e-7	3.201e-5
Type I diabetes mellitus	KEGG	7	HLA-C, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DQB1, FASLG, INS	44	166	11.51	2.116e-6	9.325e-5
Chylomicron assembly	Reactome	4	APOB, APOE, APOC2, APOC3	9	166	32.16	4.202e-6	1.679e-4
Autoimmune thyroid disease	KEGG	7	HLA-C, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DQB1, FASLG, IFNA2	54	166	9.38	8.709e-6	3.063e-4
PPAR signaling pathway	KEGG	8	APOA5, ANGPTL4, CYP7A1, LPL, PLTP, FADS2, PPARA, APOC3	76	166	7.62	9.548e-6	3.292e-4
Assembly of active LPL and LIPC lipase complexes	Reactome	4	ANGPTL4, LIPC, LPL, LMF1	11	166	26.31	1.077e-5	3.640e-4
Allograft rejection	KEGG	6	HLA-C, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DQB1, FASLG	39	166	11.13	1.424e-5	4.569e-4
Toxoplasmosis	KEGG	9	HLA-DQA1, HLA-DRA, HLA-DRB1, LDLR, HLA-DQB1, HSPA1B, JAK2, AKT1, LAMC1	112	166	5.81	2.411e-5	7.125e-4
Fat digestion and absorption	KEGG	6	ABCG8, APOB, PLA2G12B, ABCA1, NPC1L1, SCARB1	43	166	10.10	2.543e-5	7.446e-4
Graft-versus-host disease	KEGG	6	HLA-C, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DQB1, FASLG	45	166	9.65	3.320e-5	9.224e-4
Bile secretion	KEGG	8	ABCG8, CYP7A1, HMGCR, LDLR, ABCB1, SCARB1, UGT2B15, UGT2B17	90	166	6.43	3.332e-5	9.253e-4