# GeDiPNet Cluster 25 -- Pairs Within Cluster -- generated 2026-10-07 14:21:09
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected across all tested pairs. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 17:17:47.
Disease A	Disease B	Similarity Score	Shared Genes	P-value	FDR Q-value
Coloboma	Congenital ocular coloboma	0.35484	11	3.649e-29	1.084e-27
Coloboma	Congenital iris coloboma	0.31250	5	4.166e-16	6.431e-15
Cleft eyelid	Congenital iris coloboma	0.66667	4	2.135e-15	3.133e-14
Cleft eyelid	Coloboma	0.25000	4	5.830e-13	7.216e-12
Congenital iris coloboma	Congenital ocular coloboma	0.14286	4	3.189e-11	3.347e-10
Cleft eyelid	Congenital ocular coloboma	0.10714	3	1.708e-8	1.345e-7
Gorlin syndrome	nevoid basal cell carcinoma syndrome	0.40000	2	5.062e-8	3.718e-7
Commissural facial cleft	Tessier facial cleft	0.33333	2	8.436e-8	5.953e-7
Cleft eyelid	Commissural facial cleft	0.25000	2	5.060e-7	3.149e-6
Commissural facial cleft	Congenital iris coloboma	0.22222	2	8.433e-7	5.014e-6
Cataract-corneal dystrophy syndrome	PAX6-related ocular dysgenesis	0.50000	1	6.494e-5	2.317e-4
Duplication of pituitary gland	nevoid basal cell carcinoma syndrome	0.33333	1	1.299e-4	3.908e-4
Duplication of pituitary gland	Tessier facial cleft	0.33333	1	1.299e-4	3.908e-4
Cataract-corneal dystrophy syndrome	Optic nerve disorder	0.33333	1	1.299e-4	3.908e-4
Opitz g/bbb syndrome	Tessier facial cleft	0.33333	1	1.299e-4	3.908e-4
Optic nerve disorder	Urinary retention	0.33333	1	1.299e-4	3.908e-4
Optic nerve disorder	PAX6-related ocular dysgenesis	0.33333	1	1.299e-4	3.908e-4
nevoid basal cell carcinoma syndrome	Tessier facial cleft	0.25000	1	2.598e-4	6.484e-4
Arthrogryposis with oculomotor limitation and retinal anomalies	Gorlin syndrome	0.20000	1	2.598e-4	6.484e-4
Cleft eyelid	PAX6-related ocular dysgenesis	0.20000	1	2.598e-4	6.484e-4
Cataract-corneal dystrophy syndrome	Cleft eyelid	0.20000	1	2.598e-4	6.484e-4
Cataract-corneal dystrophy syndrome	Paranoid schizophrenia	0.20000	1	2.598e-4	6.484e-4
Duplication of pituitary gland	Gorlin syndrome	0.20000	1	2.598e-4	6.484e-4
Paranoid schizophrenia	PAX6-related ocular dysgenesis	0.20000	1	2.598e-4	6.484e-4
Auriculocondylar syndrome	Urinary retention	0.20000	1	2.598e-4	6.484e-4
Commissural facial cleft	Opitz g/bbb syndrome	0.16667	1	3.247e-4	7.680e-4
Congenital iris coloboma	PAX6-related ocular dysgenesis	0.16667	1	3.247e-4	7.680e-4
Commissural facial cleft	Duplication of pituitary gland	0.16667	1	3.247e-4	7.680e-4
Cataract-corneal dystrophy syndrome	Congenital iris coloboma	0.16667	1	3.247e-4	7.680e-4
Commissural facial cleft	PAX6-related ocular dysgenesis	0.16667	1	3.247e-4	7.680e-4
Cataract-corneal dystrophy syndrome	Commissural facial cleft	0.16667	1	3.247e-4	7.680e-4
Gorlin syndrome	Tessier facial cleft	0.16667	1	5.195e-4	1.058e-3
Auriculocondylar syndrome	Optic nerve disorder	0.16667	1	5.195e-4	1.058e-3
Optic nerve disorder	Paranoid schizophrenia	0.16667	1	5.195e-4	1.058e-3
Congenital ocular coloboma	Neurooculocardio-genitourinary syndrome	0.03704	1	1.689e-3	2.529e-3
Cataract-microcornea-metabolic syndrome	Congenital ocular coloboma	0.03704	1	1.689e-3	2.529e-3