# GeDiPNet Cluster 249 -- Enriched Pathways -- generated 2026-10-07 19:45:12
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Adherens junction	KEGG	3	KRIT1, CCM2, PDCD10	93	13	29.80	1.215e-4	2.623e-3
Downstream signal transduction	Reactome	2	PIK3CA, RASA1	29	13	63.71	4.320e-4	7.108e-3
Sterols are 12-hydroxylated by CYP8B1	Reactome	1	PTGIS	2	13	461.92	2.164e-3	2.417e-2
PD-L1 expression and PD-1 checkpoint pathway in cancer	KEGG	2	PIK3CA, MAP3K3	90	13	20.53	4.105e-3	3.842e-2
Synthesis of 5-eicosatetraenoic acids	Reactome	1	PON1	6	13	153.97	6.478e-3	5.190e-2
MET activates PI3K/AKT signaling	Reactome	1	PIK3CA	6	13	153.97	6.478e-3	5.190e-2
IRS-mediated signalling	Reactome	1	PIK3CA	6	13	153.97	6.478e-3	5.190e-2
Neurotrophin signaling pathway	KEGG	2	PIK3CA, MAP3K3	120	13	15.40	7.186e-3	5.561e-2
PI3K/AKT activation	Reactome	1	PIK3CA	9	13	102.65	9.703e-3	6.739e-2
PI3K events in ERBB4 signaling	Reactome	1	PIK3CA	10	13	92.38	1.078e-2	7.186e-2
Signaling by FGFR3 fusions in cancer	Reactome	1	PIK3CA	10	13	92.38	1.078e-2	7.186e-2
Signaling by FGFR4 in disease	Reactome	1	PIK3CA	11	13	83.99	1.185e-2	7.599e-2
Costimulation by the CD28 family	Reactome	1	PIK3CA	11	13	83.99	1.185e-2	7.599e-2
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Reactome	1	PTGIS	12	13	76.99	1.292e-2	7.945e-2
Eicosanoids	Reactome	1	PTGIS	12	13	76.99	1.292e-2	7.945e-2