# GeDiPNet Cluster 245 -- Enriched Pathways -- generated 2026-10-07 07:14:33
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Transferrin endocytosis and recycling	Reactome	4	TF, STEAP3, TFRC, HFE	31	12	129.14	1.772e-8	1.440e-6
Ferroptosis	KEGG	4	TF, SLC11A2, STEAP3, TFRC	42	12	95.32	6.266e-8	4.358e-6
TGF-beta signaling pathway	KEGG	4	TF, TNF, TFRC, HFE	108	12	37.07	2.896e-6	1.205e-4
Hematopoietic cell lineage	KEGG	3	TNF, TFRC, ITGA2	100	12	30.03	1.167e-4	2.536e-3
Iron uptake and transport	Reactome	2	TF, SLC11A2	28	12	71.49	3.410e-4	5.925e-3
Detoxification of Reactive Oxygen Species	Reactome	2	SOD1, GPX1	34	12	58.87	5.044e-4	8.012e-3
Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)	Reactome	1	SLC11A2	1	12	1000.83	9.992e-4	1.354e-2
Mineral absorption	KEGG	2	TF, SLC11A2	61	12	32.81	1.621e-3	1.959e-2
Virion - Rotavirus	KEGG	1	ITGA2	2	12	500.42	1.997e-3	2.278e-2
Hypertrophic cardiomyopathy	KEGG	2	TNF, ITGA2	99	12	20.22	4.207e-3	3.903e-2
Dilated cardiomyopathy	KEGG	2	TNF, ITGA2	105	12	19.06	4.719e-3	4.219e-2
Cargo recognition for clathrin-mediated endocytosis	Reactome	2	TF, TFRC	106	12	18.88	4.807e-3	4.275e-2
Amyotrophic lateral sclerosis	KEGG	3	TNF, SOD1, GPX1	368	12	8.16	5.109e-3	4.436e-2
HIF-1 signaling pathway	KEGG	2	TF, TFRC	110	12	18.20	5.167e-3	4.468e-2
TNFR1-mediated ceramide production	Reactome	1	TNF	6	12	166.81	5.981e-3	4.925e-2