# GeDiPNet Cluster 241 -- Enriched Pathways -- generated 2026-10-10 06:48:53
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-10 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
The canonical retinoid cycle in rods (twilight vision)	Reactome	3	ABCA4, RHO, RPE65	20	16	112.59	2.181e-6	1.022e-4
Phototransduction	KEGG	2	RHO, GUCY2D	29	16	51.77	6.616e-4	1.028e-2
Inactivation, recovery and regulation of the phototransduction cascade	Reactome	2	RHO, GUCY2D	33	16	45.49	8.577e-4	1.245e-2
Activation of the phototransduction cascade	Reactome	1	RHO	9	16	83.40	1.193e-2	7.898e-2
Purine metabolism	KEGG	2	ATIC, GUCY2D	128	16	11.73	1.227e-2	8.057e-2
Opsins	Reactome	1	RHO	10	16	75.06	1.325e-2	8.406e-2
Purine ribonucleoside monophosphate biosynthesis	Reactome	1	ATIC	12	16	62.55	1.588e-2	9.382e-2
Passive transport by Aquaporins	Reactome	1	AQP4	12	16	62.55	1.588e-2	9.382e-2
Retinoid cycle disease events	Reactome	1	ABCA4	13	16	57.74	1.719e-2	9.836e-2
Processing of SMDT1	Reactome	1	PMPCA	16	16	46.91	2.112e-2	1.103e-1
VxPx cargo-targeting to cilium	Reactome	1	RHO	21	16	35.74	2.763e-2	1.285e-1
Cholesterol biosynthesis	Reactome	1	ARV1	21	16	35.74	2.763e-2	1.285e-1
Antifolate resistance	KEGG	1	ATIC	30	16	25.02	3.925e-2	1.550e-1
One carbon pool by folate	KEGG	1	ATIC	38	16	19.75	4.947e-2	1.757e-1
Molecules associated with elastic fibres	Reactome	1	EFEMP1	38	16	19.75	4.947e-2	1.757e-1