# GeDiPNet Cluster 24 -- Enriched Pathways -- generated 2026-10-09 08:02:34
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
AGE-RAGE signaling pathway in diabetic complications	KEGG	18	PLCE1, AGT, COL4A1, COL4A4, COL4A5, EDN1, FN1, SERPINE1, TGFB1, COL4A3, ICAM1, COL1A1	101	240	8.92	1.167e-12	2.285e-10
Amoebiasis	KEGG	16	ACTN4, COL4A1, COL4A4, COL4A5, FN1, GNAQ, LAMA5, LAMB2, NOS2, TGFB1, COL4A3, ITGB2	103	240	7.77	1.879e-10	2.402e-8
Laminin interactions	Reactome	9	COL4A1, COL4A4, COL4A5, ITGB4, LAMA5, LAMB2, COL4A3, COL4A2, ITGA3	28	240	16.08	2.171e-9	2.109e-7
Focal adhesion	KEGG	20	ACTN4, EMP2, COL4A1, COL4A4, COL4A5, FN1, ITGB4, LAMA5, LAMB2, SPP1, GRB2, COL4A3	203	240	4.93	4.025e-9	3.725e-7
Extracellular matrix organization	Reactome	7	COL4A1, COL4A4, COL4A5, FN1, COL4A3, COL1A1, COL4A2	15	240	23.35	6.549e-9	5.719e-7
Type I diabetes mellitus	KEGG	10	CD28, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB5, IL1B, IL2, FAS, HLA-B, IFNG	44	240	11.37	1.151e-8	9.293e-7
Nephrin family interactions	Reactome	6	NPHS1, NPHS2, KIRREL2, NCK1, NCK2, KIRREL1	10	240	30.03	1.175e-8	9.451e-7
Non-integrin membrane-ECM interactions	Reactome	8	COL4A1, COL4A4, COL4A5, FN1, COL4A3, COL1A1, COL4A2, FGF2	24	240	16.68	1.263e-8	1.003e-6
Graft-versus-host disease	KEGG	10	CD28, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB5, IL1B, IL2, FAS, HLA-B, IFNG	45	240	11.12	1.455e-8	1.142e-6
ECM-receptor interaction	KEGG	13	COL4A1, COL4A4, COL4A5, FN1, ITGB4, LAMA5, LAMB2, SPP1, COL4A3, COL1A1, COL4A2, ITGA3	89	240	7.31	2.144e-8	1.610e-6
Allograft rejection	KEGG	9	CD28, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB5, IL2, FAS, HLA-B, IFNG	39	240	11.55	5.498e-8	3.737e-6
Postmitotic nuclear pore complex (NPC) reformation	Reactome	7	NUP107, NUP133, NUP160, NUP205, NUP37, NUP85, NUP93	22	240	15.92	1.540e-7	9.222e-6
Interleukin-4 and Interleukin-13 signaling	Reactome	13	FN1, LAMA5, NOS2, TGFB1, GATA3, ICAM1, ITGB2, VIM, FGF2, IL1B, POMC, PTGS2	108	240	6.02	2.244e-7	1.271e-5
Anchoring fibril formation	Reactome	6	COL4A1, COL4A4, COL4A5, COL4A3, COL1A1, COL4A2	15	240	20.02	2.575e-7	1.434e-5
Leishmaniasis	KEGG	11	NOS2, TGFB1, ITGB2, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB5, IL1B, CYBB, IFNG, PTGS2	78	240	7.06	3.860e-7	2.049e-5